Imperial College London
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ProfessorGrahamCooke

Faculty of Medicine, Department of Infectious Disease

Vice Dean (Research); Professor of Infectious Diseases
 
 
 
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Contact

 

g.cooke

 
 
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Location

 

Infectious Diseases SectionMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Huang:2010:10.1038/ncomms1100,
author = {Huang, KH and Bonsall, D and Katzourakis, A and Thomson, EC and Fidler, SJ and Main, J and Muir, D and Weber, JN and Frater, AJ and Phillips, RE and Pybus, OG and Goulder, PJ and McClure, MO and Cooke, GS and Klenerman, P},
doi = {10.1038/ncomms1100},
journal = {Nat Commun},
title = {B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection.},
url = {http://dx.doi.org/10.1038/ncomms1100},
volume = {1},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investigate the role of B cells in an HIV-infected patient. The HIV-1(+) patient studied here was not taking antiretroviral drugs and was treated for pre-existing low-grade lymphoplasmacytoid lymphoma by depletion of CD20+ B cells using rituximab. We demonstrate that B-cell depletion results in a decline in autologous neutralizing antibody (NAb) responses and a 1.7 log(10) rise in HIV-1 plasma viral load (pVL). The recovery of NAbs results in a decline in pVL. The HIV-1 sequences diversify and NAb-resistant mutants are subsequently selected. These data suggest that B-cell function can contribute to the long-term control of pVL, and that NAbs may be more important in controlling chronic HIV-1 infection than previously suspected.
AU  - Huang,KH
AU  - Bonsall,D
AU  - Katzourakis,A
AU  - Thomson,EC
AU  - Fidler,SJ
AU  - Main,J
AU  - Muir,D
AU  - Weber,JN
AU  - Frater,AJ
AU  - Phillips,RE
AU  - Pybus,OG
AU  - Goulder,PJ
AU  - McClure,MO
AU  - Cooke,GS
AU  - Klenerman,P
DO  - 10.1038/ncomms1100
PY  - 2010///
SN  - 2041-1723
TI  - B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection.
T2  - Nat Commun
UR  - http://dx.doi.org/10.1038/ncomms1100
UR  - http://www.nature.com/ncomms/journal/v1/n7/full/ncomms1100.html
UR  - http://hdl.handle.net/10044/1/20039
VL  - 1
ER  -
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