Publications

BibTex format

@article{Roth-Walter:2019:10.1111/all.13642,
author = {Roth-Walter, F and Adcock, IM and Benito-Villalvilla, C and Bianchini, R and Bjermer, L and Caramori, G and Cari, L and Chung, KF and Diamant, Z and Eguiluz-Gracia, I and Knol, E and Kolios, A and Levi-Schaffer, F and Nocentini, G and Palomares, O and Puzzovio, PG and Redegeld, F and Van, Esch B and Stellato, C},
doi = {10.1111/all.13642},
journal = {Allergy},
pages = {432--448},
title = {Comparing biologicals and small molecule drug therapies for chronic respiratory diseases},
url = {http://dx.doi.org/10.1111/all.13642},
volume = {74},
year = {2019}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), together with their comorbidities, bear a significant burden on public health. Increased appreciation of molecular networks underlying inflammatory airway disease needs to be translated into new therapies for distinct phenotypes not controlled by current treatment regimens. On the other hand, development of new safe and effective therapies for such respiratory diseases is an arduous and expensive process. Antibody-based (biological) therapies are successful in treating certain respiratory conditions not controlled by standard therapies such as severe allergic and refractory eosinophilic severe asthma, while in other inflammatory respiratory diseases, such as COPD, biologicals are having a more limited impact. Small molecule drug (SMD)-based therapies represent an active field in pharmaceutical research and development. SMDs expand biologicals' therapeutic targets by reaching the intracellular compartment by delivery as either an oral or topically-based formulation, offering both convenience and lower costs. Aim of this review is to compare and contrast the distinct pharmacological properties and clinical applications of SMDs- and antibody-based treatment strategies, their limitations and challenges, in order to highlight how they should be integrated for their optimal utilization and to fill the critical gaps in current treatment for chronic inflammatory respiratory diseases. This article is protected by copyright. All rights reserved.
AU  - Roth-Walter,F
AU  - Adcock,IM
AU  - Benito-Villalvilla,C
AU  - Bianchini,R
AU  - Bjermer,L
AU  - Caramori,G
AU  - Cari,L
AU  - Chung,KF
AU  - Diamant,Z
AU  - Eguiluz-Gracia,I
AU  - Knol,E
AU  - Kolios,A
AU  - Levi-Schaffer,F
AU  - Nocentini,G
AU  - Palomares,O
AU  - Puzzovio,PG
AU  - Redegeld,F
AU  - Van,Esch B
AU  - Stellato,C
DO  - 10.1111/all.13642
EP  - 448
PY  - 2019///
SN  - 0105-4538
SP  - 432
TI  - Comparing biologicals and small molecule drug therapies for chronic respiratory diseases
T2  - Allergy
UR  - http://dx.doi.org/10.1111/all.13642
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30353939
UR  - http://hdl.handle.net/10044/1/64169
VL  - 74
ER  -

Download

ProfessorIanAdcock

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)