Imperial College London
Alternate

ProfessorJulianMarchesi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Digestive Health
 
 
 
//

Contact

 

+44 (0)20 3312 6197j.marchesi

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Dos:2023:10.1016/j.mib.2023.102292,
author = {Dos, Santos Correia G and Marchesi, J and MacIntyre, D},
doi = {10.1016/j.mib.2023.102292},
journal = {Current Opinion in Microbiology},
pages = {1--11},
title = {Moving beyond DNA: towards functional analysis of the vaginal microbiome by non-sequencing-based methods},
url = {http://dx.doi.org/10.1016/j.mib.2023.102292},
volume = {73},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Over the last two decades, sequencing-based methods have revolutionised our understanding of niche-specific microbial complexity. In the lower female reproductive tract, these approaches have enabled identification of bacterial compositional structures associated with health and disease. Application of metagenomics and metatranscriptomics strategies have provided insight into the putative function of these communities but it is increasingly clear that direct measures of microbial and host cell function are required to understand the contribution of microbe–host interactions to pathophysiology. Here we explore and discuss current methods and approaches, many of which rely upon mass-spectrometry, being used to capture functional insight into the vaginal mucosal interface. In addition to improving mechanistic understanding, these methods offer innovative solutions for the development of diagnostic and therapeutic strategies designed to improve women’s health.
AU  - Dos,Santos Correia G
AU  - Marchesi,J
AU  - MacIntyre,D
DO  - 10.1016/j.mib.2023.102292
EP  - 11
PY  - 2023///
SN  - 1369-5274
SP  - 1
TI  - Moving beyond DNA: towards functional analysis of the vaginal microbiome by non-sequencing-based methods
T2  - Current Opinion in Microbiology
UR  - http://dx.doi.org/10.1016/j.mib.2023.102292
UR  - https://www.sciencedirect.com/science/article/pii/S1369527423000292
UR  - http://hdl.handle.net/10044/1/102981
VL  - 73
ER  -
Download