Imperial College London
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Dr Julie McDonald

Faculty of Natural Sciences, Department of Life Sciences

Lecturer (MRC-CMBI)
 
 
 
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Contact

 

+44 (0)20 7594 5247julie.mcdonald Website

 
 
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Location

 

1.44Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mullish:2018:10.3332/ecancer.2018.864,
author = {Mullish, BH and Osborne, LS and Marchesi, JR and McDonald, JAK},
doi = {10.3332/ecancer.2018.864},
journal = {Ecancermedicalscience},
pages = {1--11},
title = {The implementation of omics technologies in cancer microbiome research},
url = {http://dx.doi.org/10.3332/ecancer.2018.864},
volume = {12},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Whilst the interplay between host genetics and the environment plays a pivotal role in the aetiopathogenesis of cancer, there are other key contributors of importance as well.  One such factor of central and growing interest is the contribution of the microbiota to cancer.  Even though the field is only a few years old, investigation of the ’cancer microbiome’ has already lead to major advances in knowledge of the basic biology of cancer risk and progression, opened novel avenues for biomarkers and diagnostics, and given better understanding of mechanisms underlying response to therapy.  Recent developments in microbial DNA sequencing techniques (and the bioinformatics required for analysis of these datasets) has allowed much more in-depth profiling of the structure of microbial communities than was previously possible.  However, for more complete assessment of the functional implications of microbial changes, there is a growing recognition of the importance of the integration of microbial profiling with other ‘omics modalities, with metabonomics (metabolite profiling) and proteomics (protein profiling) both gaining particular recent attention.  In this review, we give an overview of some of the key scientific techniques being used to unravel the role of the cancer microbiome.  We have aimed to highlight practical aspects related to sample collection and preparation, choice of modality of analysis, and examples of where different ‘omics technologies have been complementary to each other to highlighting the significance of the cancer microbiome.
AU  - Mullish,BH
AU  - Osborne,LS
AU  - Marchesi,JR
AU  - McDonald,JAK
DO  - 10.3332/ecancer.2018.864
EP  - 11
PY  - 2018///
SN  - 1754-6605
SP  - 1
TI  - The implementation of omics technologies in cancer microbiome research
T2  - Ecancermedicalscience
UR  - http://dx.doi.org/10.3332/ecancer.2018.864
UR  - https://ecancer.org/journal/12/864-the-implementation-of-omics-technologies-in-cancer-microbiome-research.php#plos-widget
UR  - https://ecancer.org/journal/12/full/864-the-implementation-of-omics-technologies-in-cancer-microbiome-research.php
UR  - http://hdl.handle.net/10044/1/60976
VL  - 12
ER  -
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