Imperial College London
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Professor Lesley Hoyles

Faculty of Medicine, Department of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

lesley.hoyles11 Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shoaie:2015:10.1016/j.cmet.2015.07.001,
author = {Shoaie, S and Ghaffari, P and Kovatcheva-Datchary, P and Mardinoglu, A and Sen, P and Pujos-Guillot, E and de, Wouters T and Juste, C and Rizkalla, S and Chilloux, J and Hoyles, L and Nicholson, JK and MICRO-Obes, consortium and Dore, J and Dumas, ME and Clement, K and Bäckhed, F and Nielsen, J},
doi = {10.1016/j.cmet.2015.07.001},
journal = {Cell Metabolism},
pages = {320--331},
title = {Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome},
url = {http://dx.doi.org/10.1016/j.cmet.2015.07.001},
volume = {22},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The human gut microbiome is known to be associated with various human disorders, but a major challenge is to go beyond association studies and elucidate causalities. Mathematical modeling of the human gut microbiome at a genome scale is a useful tool to decipher microbe-microbe, diet-microbe and microbe-host interactions. Here, we describe the CASINO (Community And Systems-level INteractive Optimization) toolbox, a comprehensive computational platform for analysis of microbial communities through metabolic modeling. We first validated the toolbox by simulating and testing the performance of single bacteria and whole communities in vitro. Focusing on metabolic interactions between the diet, gut microbiota, and host metabolism, we demonstrated the predictive power of the toolbox in a diet-intervention study of 45 obese and overweight individuals and validated our predictions by fecal and blood metabolomics data. Thus, modeling could quantitatively describe altered fecal and serum amino acid levels in response to diet intervention.
AU  - Shoaie,S
AU  - Ghaffari,P
AU  - Kovatcheva-Datchary,P
AU  - Mardinoglu,A
AU  - Sen,P
AU  - Pujos-Guillot,E
AU  - de,Wouters T
AU  - Juste,C
AU  - Rizkalla,S
AU  - Chilloux,J
AU  - Hoyles,L
AU  - Nicholson,JK
AU  - MICRO-Obes,consortium
AU  - Dore,J
AU  - Dumas,ME
AU  - Clement,K
AU  - Bäckhed,F
AU  - Nielsen,J
DO  - 10.1016/j.cmet.2015.07.001
EP  - 331
PY  - 2015///
SN  - 1932-7420
SP  - 320
TI  - Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2015.07.001
UR  - http://hdl.handle.net/10044/1/28222
VL  - 22
ER  -
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