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@article{Gething:2016:10.1056/NEJMoa1606701,
author = {Gething, PW and Casey, DC and Weiss, DJ and Bisanzio, D and Bhatt, S and Cameron, E and Battle, KE and Dalrymple, U and Rozier, J and Rao, PC and Kutz, MJ and Barber, RM and Huynh, C and Shackelford, KA and Coates, MM and Nguyen, G and Fraser, MS and Kulikoff, R and Wang, H and Naghavi, M and Smith, DL and Murray, CJL and Hay, SI and Lim, SS},
doi = {10.1056/NEJMoa1606701},
journal = {New England Journal of Medicine},
pages = {2435--2445},
title = {Mapping Plasmodium falciparum mortality in Africa between 1990 and 2015},
url = {http://dx.doi.org/10.1056/NEJMoa1606701},
volume = {375},
year = {2016}
}

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TY  - JOUR
AB  - BACKGROUND:Malaria control has not been routinely informed by the assessment of subnationalvariation in malaria deaths. We combined data from the Malaria Atlas Project andthe Global Burden of Disease Study to estimate malaria mortality across subSaharanAfrica on a grid of 5 km2 from 1990 through 2015.METHODS:We estimated malaria mortality using a spatiotemporal modeling framework ofgeolocated data (i.e., with known latitude and longitude) on the clinical incidenceof malaria, coverage of antimalarial drug treatment, case fatality rate, and populationdistribution according to age.RESULTS:Across sub-Saharan Africa during the past 15 years, we estimated that there wasan overall decrease of 57% (95% uncertainty interval, 46 to 65) in the rate of malariadeaths, from 12.5 (95% uncertainty interval, 8.3 to 17.0) per 10,000 populationin 2000 to 5.4 (95% uncertainty interval, 3.4 to 7.9) in 2015. This led to an overalldecrease of 37% (95% uncertainty interval, 36 to 39) in the number of malariadeaths annually, from 1,007,000 (95% uncertainty interval, 666,000 to 1,376,000)to 631,000 (95% uncertainty interval, 394,000 to 914,000). The share of malariadeaths among children younger than 5 years of age ranged from more than 80%at a rate of death of more than 25 per 10,000 to less than 40% at rates below 1 per10,000. Areas with high malaria mortality (>10 per 10,000) and low coverage (<50%)of insecticide-treated bed nets and antimalarial drugs included much of Nigeria,Angola, and Cameroon and parts of the Central African Republic, Congo, Guinea,and Equatorial Guinea.CONCLUSIONS:We estimated that there was an overall decrease of 57% in the rate of death frommalaria across sub-Saharan Africa over the past 15 years and identified severalcountries in which high rates of death were associated with low coverage of antimalarialtreatment and prevention programs.
AU  - Gething,PW
AU  - Casey,DC
AU  - Weiss,DJ
AU  - Bisanzio,D
AU  - Bhatt,S
AU  - Cameron,E
AU  - Battle,KE
AU  - Dalrymple,U
AU  - Rozier,J
AU  - Rao,PC
AU  - Kutz,MJ
AU  - Barber,RM
AU  - Huynh,C
AU  - Shackelford,KA
AU  - Coates,MM
AU  - Nguyen,G
AU  - Fraser,MS
AU  - Kulikoff,R
AU  - Wang,H
AU  - Naghavi,M
AU  - Smith,DL
AU  - Murray,CJL
AU  - Hay,SI
AU  - Lim,SS
DO  - 10.1056/NEJMoa1606701
EP  - 2445
PY  - 2016///
SN  - 1533-4406
SP  - 2435
TI  - Mapping Plasmodium falciparum mortality in Africa between 1990 and 2015
T2  - New England Journal of Medicine
UR  - http://dx.doi.org/10.1056/NEJMoa1606701
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000390091500007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/44812
VL  - 375
ER  -

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