Imperial College London
Alternate

Prof Steve Matthews

Faculty of Natural Sciences, Department of Life Sciences

Professor of Chemical and Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 5315s.j.matthews Website

 
 
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Location

 

602Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jønsson:2016:10.1016/j.bbapap.2016.11.017,
author = {Jønsson, R and Liu, B and Struve, C and Yang, Y and Jenssen, H and Krogfelt, K and Matthews, SJ},
doi = {10.1016/j.bbapap.2016.11.017},
journal = {BBA Protein and Proteomics},
pages = {304--311},
title = {Structural and functional studies of Escherichia coli Aggregative Adherence Fimbriae (AAF/V) reveal a deficiency in extracellular matrix binding},
url = {http://dx.doi.org/10.1016/j.bbapap.2016.11.017},
volume = {1865},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Enteroaggregative Escherichia coli (EAEC) is an emerging cause of acute and persistent diarrhea worldwide. The pathogenesis of different EAEC stains is complicated, however, the early essential step begins with attachment of EAEC to intestinal mucosa via aggregative adherence fimbriae (AAFs). Currently, five different variants have been identified, which all share a degree of similarity in the gene organization of their operons and sequences. Here, we report the solution structure of Agg5A from the AAF/V variant. While preserving the major structural features shared by all AAF members, only Agg5A possesses an inserted helix at the beginning of the donor strand, which together with altered surface electrostatics, renders the protein unable to interact with fibronectin. Hence, here we characterize the first AAF variant with a binding mode that varies from previously described AAFs
AU  - Jønsson,R
AU  - Liu,B
AU  - Struve,C
AU  - Yang,Y
AU  - Jenssen,H
AU  - Krogfelt,K
AU  - Matthews,SJ
DO  - 10.1016/j.bbapap.2016.11.017
EP  - 311
PY  - 2016///
SN  - 1570-9639
SP  - 304
TI  - Structural and functional studies of Escherichia coli Aggregative Adherence Fimbriae (AAF/V) reveal a deficiency in extracellular matrix binding
T2  - BBA Protein and Proteomics
UR  - http://dx.doi.org/10.1016/j.bbapap.2016.11.017
UR  - http://hdl.handle.net/10044/1/42957
VL  - 1865
ER  -
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