Summary
My group uses multidisciplinary computational and experimental biophysical approaches to understand pathways that involve biological membranes at the molecular level of detail. The lab is currently supported by a UKRI Future Leaders Fellowship awarded in 2020.
Research focus areas include:
Mitochondrial pathways involved in ageing and age-related disorders; targetting of nanoparticles and viral vaccines to membranes (collaborations with Bracewell group UCL and AstraZeneca); lipid modulation of membrane proteins; rational design of lipid-like molecules in biotherapeutics; relationship networks to characterise links between ageing and space flight (in collaboration with Vector Space BioSciences).
Current funded opportunities:
A BBSRC PhD Studentship in “Cryogenic electron microscopy-based understanding of viral vector heterogeneity to aide process development" co-supervised with Prof. Dan Bracewell, UCL, is available beginning October 2023.
Selected Publications
Journal Articles
Khalid S, Rouse SL, 2020, Simulation of subcellular structures, Current Opinion in Structural Biology, Vol:61, ISSN:0959-440X, Pages:167-172
Miliara X, Tatsuta T, Berry J-L, et al., 2019, Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-15
Chorev DS, Baker LA, Wu D, et al., 2018, Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry, Science, Vol:362, ISSN:0036-8075, Pages:829-+
Rouse SL, Matthews SJ, Dueholm MS, 2018, Ecology and biogenesis of functional amyloids in pseudomonas, Journal of Molecular Biology, Vol:430, ISSN:0022-2836, Pages:3685-3695
Darvill N, Blake T, Rouse S, et al., 2018, Structural basis of phosphatidic acid sensing by APH in apicomplexan parasites, Structure, Vol:26, ISSN:0969-2126, Pages:1059-1071.e6
rouse S, hawthorne, berry, et al., 2017, A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis, Nature Communications, Vol:8, ISSN:2041-1723