Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

UKRI Future Leaders Fellow







Sir Ernst Chain BuildingSouth Kensington Campus





My group uses multidisciplinary computational and experimental biophysical approaches to understand pathways that involve biological membranes at the molecular level of detail. The lab is currently supported by a UKRI Future Leaders Fellowship awarded in 2020

Research focus areas include:

Mitochondrial pathways involved in ageing and age-related disorders; targetting of nanoparticles and viral vaccines to membranes (collaborations with Bracewell group UCL and AstraZeneca); lipid modulation of membrane proteins; rational design of lipid-like molecules in biotherapeutics; relationship networks to characterise links between ageing and space flight (in collaboration with Vector Space BioSciences).

Current funded opportunities:

A BBSRC PhD Studentship in “Cryogenic electron microscopy-based understanding of viral vector heterogeneity to aide process development" co-supervised with Prof. Dan Bracewell, UCL, is available beginning October 2023

Selected Publications

Journal Articles

Khalid S, Rouse SL, 2020, Simulation of subcellular structures, Current Opinion in Structural Biology, Vol:61, ISSN:0959-440X, Pages:167-172

Miliara X, Tatsuta T, Berry J-L, et al., 2019, Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-15

Chorev DS, Baker LA, Wu D, et al., 2018, Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry, Science, Vol:362, ISSN:0036-8075, Pages:829-+

Rouse SL, Matthews SJ, Dueholm MS, 2018, Ecology and biogenesis of functional amyloids in pseudomonas, Journal of Molecular Biology, Vol:430, ISSN:0022-2836, Pages:3685-3695

Darvill N, Blake T, Rouse S, et al., 2018, Structural basis of phosphatidic acid sensing by APH in apicomplexan parasites, Structure, Vol:26, ISSN:0969-2126, Pages:1059-1071.e6

rouse S, hawthorne, berry, et al., 2017, A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis, Nature Communications, Vol:8, ISSN:2041-1723

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