Summary
Sadra Sadeh leads the Computational Lab of Neural Dynamics at Imperial College London. His group develops computational and theoretical platforms to direct neuroscientific research and neurotechnological innovation.
His research contributes to this endeavour through data-constrained computational modelling and theoretical analysis of large-scale neuronal networks. These models help understand the computational mechanisms underlying the operation of networks of neurons, which remains a major challenge in neuroscience due to the complexity of neuronal interactions in the brain. Research in the Lab will bridge the gap between structural connectivity of these networks and their functional properties, emerging at the level of activity dynamics, and enabled by dynamic reorganisation of the network as a result of learning. It ultimately sheds light on the central neuroscience questions, such as the mechanisms of sensorimotor processing and learning in healthy brains, and enables the design of better brain machine interface and therapeutic solutions to brain diseases.
Sadra Sadeh is the recipient of the Wellcome Trust Career Development Award. He did his postdoctoral research at University College London (Department of Neuroscience, Physiology and Pharmacology) and Imperial College London (Department of Bioengineering). He completed his PhD in Computational Neuroscience at the Bernstein Center Freiburg, University of Freiburg.
Publications
Journals
Feitosa Tomé D, Zhang Y, Aida T, et al., 2024, Dynamic and selective engrams emerge with memory consolidation, Nature Neuroscience, Vol:27, ISSN:1097-6256, Pages:561-572
Radulescu CI, Doostdar N, Zabouri N, et al., 2023, Age-related dysregulation of homeostatic control in neuronal microcircuits, Nature Neuroscience, Vol:26, ISSN:1097-6256, Pages:2158-2170
Xie Y, Sadeh S, 2023, Computational assessment of visual coding across mouse brain areas and behavioural states, Frontiers in Computational Neuroscience, Vol:17, ISSN:1662-5188
Sadeh S, Clopath C, 2022, Contribution of behavioural variability to representational drift, Elife, Vol:11, ISSN:2050-084X, Pages:1-28
Feitosa Tome D, Sadeh S, Clopath C, 2022, Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation, Nature Communications, Vol:13, ISSN:2041-1723