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@article{Saglani:2006:10.1186/1465-9921-7-46,
author = {Saglani, S and Papaioannou, G and Khoo, L and Ujita, M and Jeffery, PK and Owens, C and Hansell, DM and Payne, DN and Bush, A},
doi = {10.1186/1465-9921-7-46},
journal = {Respiratory Research},
title = {Can HRCT be used as a marker of airway remodelling in children with difficult asthma?},
url = {http://dx.doi.org/10.1186/1465-9921-7-46},
volume = {7},
year = {2006}
}

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TY  - JOUR
AB  - Background: Whole airway wall thickening on high resolution computed tomography (HRCT) isreported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) inadult asthmatics. A similar relationship in children with difficult asthma (DA), in whom RBMthickening is a known feature, may allow the use of HRCT as a non-invasive marker of airwayremodelling. We evaluated this relationship in children with DA.Methods: 27 children (median age 10.5 [range 4.1–16.7] years) with DA, underwentendobronchial biopsy from the right lower lobe and HRCT less than 4 months apart. HRCTs wereassessed for bronchial wall thickening (BWT) of the right lower lobe using semi-quantitative andquantitative scoring techniques. The semi-quantitative score (grade 0–4) was an overall assessmentof BWT of all clearly identifiable airways in HRCT scans. The quantitative score (BWT %; definedas [airway outer diameter – airway lumen diameter]/airway outer diameter ×100) was the averagescore of all airways visible and calculated using electronic endpoint callipers. RBM thickness inendobronchial biopsies was measured using image analysis. 23/27 subjects performed spirometryand the relationships between RBM thickness and BWT with airflow obstruction evaluated.Results: Median RBM thickness in endobronchial biopsies was 6.7(range 4.6 – 10.0) µm. Medianqualitative score for BWT of the right lower lobe was 1(range 0 – 1.5) and quantitative score was54.3 (range 48.2 – 65.6)%. There was no relationship between RBM thickness and BWT in the rightlower lobe using either scoring technique. No relationship was found between FEV1 and BWT orRBM thickness.Conclusion: Although a relationship between RBM thickness and BWT on HRCT has been foundin adults with asthma, this relationship does not appear to hold true in children with DA.
AU  - Saglani,S
AU  - Papaioannou,G
AU  - Khoo,L
AU  - Ujita,M
AU  - Jeffery,PK
AU  - Owens,C
AU  - Hansell,DM
AU  - Payne,DN
AU  - Bush,A
DO  - 10.1186/1465-9921-7-46
PY  - 2006///
SN  - 1465-993X
TI  - Can HRCT be used as a marker of airway remodelling in children with difficult asthma?
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/1465-9921-7-46
UR  - http://hdl.handle.net/10044/1/25199
VL  - 7
ER  -

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