Imperial College London
Portrait Picture

ProfessorSoniaSaxena

Faculty of Medicine, School of Public Health

Professor of Primary Care
 
 
 
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Contact

 

+44 (0)20 7594 0839s.saxena Website

 
 
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Location

 

332Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Skirrow:2024:10.1016/j.vaccine.2023.11.063,
author = {Skirrow, H and Foley, K and Bedford, H and Lewis, C and Whittaker, E and Costelloe, C and Saxena, S},
doi = {10.1016/j.vaccine.2023.11.063},
journal = {Vaccine},
pages = {322--331},
title = {Impact of pregnancy vaccine uptake and socio-demographic determinants on subsequent childhood Measles, Mumps and Rubella vaccine uptake: a UK birth cohort study},
url = {http://dx.doi.org/10.1016/j.vaccine.2023.11.063},
volume = {42},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: We examined the association between socio-demographic determinants and uptake of childhood Measles, Mumps & Rubella (MMR) vaccines and the association between pregnant women's pertussis vaccine uptake and their children's MMR vaccine uptake. METHODS: We used nationally-representative linked mother-baby electronic records from the United Kingdom's Clinical-Practice-Research-Datalink. We created a birth cohort of children born between 01.01.2000 and 12.12.2020. We estimated the proportion vaccinated with first MMR vaccine by age 2 years and first and second MMR vaccines by age 5 years. We used survival-analysis and Cox proportional hazard models to examine the association between deprivation, ethnicity and maternal age and pertussis vaccination in pregnancy and children's MMR uptake. RESULTS: Overall, 89.4 % (710,797/795,497) of children had first MMR by age 2 years and 92.6 % (736,495/795,497) by age 5 years. Among children still in the cohort when second MMR was due, 85.9 % (478,480/557,050) had two MMRs by age 5 years. Children from the most-deprived areas, children of Black ethnicity and children of mothers aged < 20 years had increased risk of being unvaccinated compared with children from the least-deprived areas, White children and children of mothers aged 31-40 years: first MMR by 5 years, adjusted Hazard Ratios (HR):0.86 (CI:0.85-0.87), HR:0.87 (CI:0.85-0.88) & HR:0.89 (CI:0.88-0.90) respectively. Deprivation was the determinant associated with the greatest risk of missed second MMR: adjusted HR:0.82 (CI:0.81-0.83). Children of mothers vaccinated in pregnancy were more likely than children of unvaccinated mothers to have MMR vaccines after adjusting for ethnicity, deprivation, and maternal age (First and Second MMRs adjusted HRs:1.43 (CI:1.41-1.45), 1.49 (CI:1.45-1.53). CONCLUSION: Children from most-deprived areas are less likely to have MMR vaccines compared with childre
AU  - Skirrow,H
AU  - Foley,K
AU  - Bedford,H
AU  - Lewis,C
AU  - Whittaker,E
AU  - Costelloe,C
AU  - Saxena,S
DO  - 10.1016/j.vaccine.2023.11.063
EP  - 331
PY  - 2024///
SN  - 0264-410X
SP  - 322
TI  - Impact of pregnancy vaccine uptake and socio-demographic determinants on subsequent childhood Measles, Mumps and Rubella vaccine uptake: a UK birth cohort study
T2  - Vaccine
UR  - http://dx.doi.org/10.1016/j.vaccine.2023.11.063
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38072757
UR  - https://www.sciencedirect.com/science/article/pii/S0264410X23014317
UR  - http://hdl.handle.net/10044/1/108778
VL  - 42
ER  -
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