Publications
651 results found
Zabron AA, Latif A, Horneffer-Van der Sluis V, et al., 2012, BILIARY LIPOCALIN-2 (LCN2) IS INDEPENDENT OF MATRIXMETALLOPROTEINASE 9 (MMP9) IN MALIGNANT JAUNDICE, UEGW, Pages: A30-A30
Ladep NG, Dona A, Holmes E, et al., 2012, Urinary Markers of Hepatocellular Carcinoma, 1307256.6
Imperial Innovations has filed 2 patents from the research work of Prof Simon Taylor-Robinson et al in the field of urinary markers of hepatocellular carcinoma: (i) priority patent application no. GB1101667.2, published as WO 2012/104585 on 9th August 2012 and (ii) priority patent application no. 1307256.6 filed on 22nd April 2013.The patent claims a method of diagnosing hepatocellular carcinoma through the analysis and detection of one or a number of urinary metabolic markers.
Williams HRT, Willsmore JD, Cox IJ, et al., 2012, Serum Metabolic Profiling in Inflammatory Bowel Disease, DIGESTIVE DISEASES AND SCIENCES, Vol: 57, Pages: 2157-2165, ISSN: 0163-2116
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- Citations: 72
Cobbold JFL, Patel D, Taylor-Robinson SD, 2012, Assessment of inflammation and fibrosis in non-alcoholic fatty liver disease by imaging-based techniques, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 27, Pages: 1281-1292, ISSN: 0815-9319
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- Citations: 26
Garvey LJ, Pavese N, Ramlackhansingh A, et al., 2012, Acute HCV/HIV Coinfection Is Associated with Cognitive Dysfunction and Cerebral Metabolite Disturbance, but Not Increased Microglial Cell Activation, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 26
Latif A, Zabron A, Horneffer-Van der Sluis V, et al., 2012, BILIARY MATRIX METALLOPROTEINASE 9 LEVELS ARE INDEPENDENT OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IN PATIENTS WITH MALIGNANT BILIARY OBSTRUCTION, GUT, Vol: 61, Pages: A211-A212, ISSN: 0017-5749
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- Citations: 1
Shariff MIF, Lewis MR, Want EJ, et al., 2012, BLOOD LIPIDOMIC PROFILING OF HEPATOCELLULAR CARCINOMA IN HUMAN AND ANIMAL STUDIES IDENTIFIES LYSOPHOSPHATIDYLCHOLINE (24,0,0), A DISCRIMINATORY BIOMARKER
Wadsworth CA, Horneffer-van der Sluis VM, Zabron A, et al., 2012, INCREASED LEVELS OF NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN (NGAL) IN THE PLASMA OF CHOLANGIOCARCINOMA PATIENTS, GUT, Vol: 61, Pages: A350-A351, ISSN: 0017-5749
Shariff MIF, Keun HC, Beckonert O, et al., 2012, PLASMA METABOLITE PROFILING IN A RAT MODEL OF HEPATOCELLULAR CARCINOMA AND THE EFFECTS OF CO-ADMINISTERED ANTIBIOTICS, GUT, Vol: 61, Pages: A405-A406, ISSN: 0017-5749
McPhail MJW, Shawcross D, Coltart I, et al., 2012, METABOLIC PROFILING OF PLASMA BY NMR SPECTROSCOPY ACCURATELY PREDICTS OUTCOME IN PATIENTS WITH DECOMPENSATED CIRRHOSIS AND ACUTE ON CHRONIC LIVER FAILURE, GUT, Vol: 61, Pages: A202-A203, ISSN: 0017-5749
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- Citations: 1
Coltart I, McPhail MJW, Want EJ, et al., 2012, PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY OF PLASMA IN PATIENTS WITH CIRRHOSIS CORRELATES WITH ARTERIAL AMMONIA BUT NOT GRADE OF HEPATIC ENCEPHALOPATHY, GUT, Vol: 61, Pages: A202-A202, ISSN: 0017-5749
Ladep NG, Khan SA, Thillainayagam AV, et al., 2012, RECENT TRENDS IN PRIMARY LIVER CANCER IN ENGLAND AND WALES, GUT, Vol: 61, Pages: A406-A407, ISSN: 0017-5749
Sheridan DA, Bridge SH, Felmlee DJ, et al., 2012, Apolipoprotein-E and hepatitis C lipoviral particles in genotype 1 infection: Evidence for an association with interferon sensitivity, JOURNAL OF HEPATOLOGY, Vol: 57, Pages: 32-38, ISSN: 0168-8278
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- Citations: 31
Syms RRA, Taylor-Robinson S, Ahmad MM, et al., 2012, Radiofrequency Detector Coils
A resonant radiofrequency (RF) detector assembly comprising a substrate, a coil formed on a front surface of the substrate, and two capacitors, each capacitor having a front plate which is formed on the front surface of the substrate and a rear plate formed on a rear surface of the substrate, the two front plates each being electrically connected to a different end of the coil, and the two rear plates being electrically connected to each other.
Cobbold JFL, Cox IJ, Brown AS, et al., 2012, Lipid profiling of pre-treatment liver biopsy tissue predicts sustained virological response in patients with chronic hepatitis C, Hepatology Research, Vol: 42, Pages: 714-720, ISSN: 1386-6346
Aim: Hepatic lipid is important in the pathogenesis and progression of hepatitis C-related liver disease. Polyunsaturated fatty acids have been shown to reduce viral replication in cell culture. Proton magic angle spinning magnetic resonance spectroscopy (1H MAS MRS) enables metabolic analysis of intact tissue. The aim was to examine the relationship between hepatic lipid composition by metabolic profiling of liver tissue at baseline and treatment response to pegylated-Interferon alfa2 and Ribavirin.Methods: Baseline liver biopsy samples from 31 patients with chronic hepatitis C were analyzed histologically and by 1H MAS MRS. Indices of lipid composition were derived and partial least squares discriminant analysis with cross-validation was used to predict treatment outcome.Results: Of 31 patients, 14 achieved sustained virological response (SVR). Lipid polyunsaturation (median (IQR)) was higher in SVR (3.41% (2.31)) than in treatment failure (TF) (2.15% (1.51)), P = 0.02. Lipid saturation was lower in SVR (85.9% (3.39)) than TF (86.7% (2.17)), P = 0.04. The total lipid content was lower in SVR (1.54% (0.81)) than TF (2.72% (3.47)), P = 0.004. Total choline to lipid ratio was higher in SVR (11.51% (9.99)) than TF (7.5% (6.82)), P = 0.007. Cross-validation correctly predicted the SVR group in 13 of 14 samples with 1 sample misclassified, and the TF group in all 17 samples.Conclusions: Lipid polyunsaturation was greater and total lipid lower in those with SVR, compared with TF. Metabolic profiling of intact liver biopsy samples predicted SVR with high accuracy. Hepatic lipid composition may impact on treatment success.
Mehta SR, Godsland IF, Thomas EL, et al., 2012, Intrahepatic Insulin Exposure, Intrahepatocellular Lipid and Regional Body Fat in Nonalcoholic Fatty Liver Disease, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 97, Pages: 2151-2159, ISSN: 0021-972X
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- Citations: 20
Thomas EL, Frost G, Taylor-Robinson SD, et al., 2012, Excess body fat in obese and normal-weight subjects, NUTRITION RESEARCH REVIEWS, Vol: 25, Pages: 150-161, ISSN: 0954-4224
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- Citations: 104
Bajaj JS, Gillevet PM, Patel NR, et al., 2012, A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy, METABOLIC BRAIN DISEASE, Vol: 27, Pages: 205-215, ISSN: 0885-7490
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- Citations: 64
Montagnese S, Schiff S, De Rui M, et al., 2012, Neuropsychological tools in hepatology: a survival guide for the clinician, JOURNAL OF VIRAL HEPATITIS, Vol: 19, Pages: 307-315, ISSN: 1352-0504
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- Citations: 15
Cobbold JFL, Patel D, Fitzpatrick JA, et al., 2012, Accuracy and reliability of microbubble ultrasound measurements for the non-invasive assessment of hepatic fibrosis in chronic hepatitis C, HEPATOLOGY RESEARCH, Vol: 42, Pages: 515-522, ISSN: 1386-6346
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- Citations: 10
Patel M, Shariff MIF, Ladep NG, et al., 2012, Hepatocellular carcinoma: diagnostics and screening, JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Vol: 18, Pages: 335-342, ISSN: 1356-1294
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- Citations: 40
Shariff MIF, Keun HC, Beckonert O, et al., 2012, PLASMA METABOLITE PROFILING IN A RAT MODEL OF HEPATOCELLULAR CARCINOMA AND THE EFFECTS OF SELECTIVE GUT DECONTAMINATION, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S125-S126, ISSN: 0168-8278
Shariff MIF, Lewis MR, Want EJ, et al., 2012, BLOOD LIPIDOMIC PROFILING OF HEPATOCELLULAR CARCINOMA IN HUMAN AND ANIMAL STUDIES IDENTIFIES LYSOPHOSPHATIDYLCHOLINE (24,0,0) AS A DISCRIMINATORY BIOMARKER, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S294-S294, ISSN: 0168-8278
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- Citations: 1
Ladep NG, Khan SA, Thillainayagam AV, et al., 2012, MORTALITY RATES OF PRIMARY LIVER CANCER ARE CONTINUING TO INCREASE GLOBALLY, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S287-S287, ISSN: 0168-8278
McPhail MJW, Shawcross D, Lewis M, et al., 2012, PLASMA PHOSHOLIPID PROFILING BY METABONOMICS: HIGHLY ACCURATE OUTCOME PREDICTION IN DECOMPENSATED CIRRHOSIS, International Liver Congress / 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S557-S557, ISSN: 0168-8278
Wadsworth CA, Horneffer-van der Sluis VM, Zabron A, et al., 2012, INCREASED LEVELS OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) IN THE PLASMA OF CHOLANGIOCARCINOMA PATIENTS, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S130-S130, ISSN: 0168-8278
Dhar A, Anstee QM, Sadiq F, et al., 2012, A ROLE FOR ANTICOAGULATION IN FIBROGENESIS: SUPPRESSION OF HUMAN HEPATIC STELLATE CELL CONTRACTILITY AND LIVER FIBROSIS IN VITRO AND VIVO, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S35-S36, ISSN: 0168-8278
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- Citations: 2
Garvey L, Pavese N, Politis M, et al., 2012, Microglial cell activation is visualised with [11C]-PK11195 Positron Emission Tomography (PET) in neuro-asymptomatic HIV infected subjects on effective antiretroviral therapy, HIV MEDICINE, Vol: 13, Pages: 4-5, ISSN: 1464-2662
Winston A, Puls R, Kerr SJ, et al., 2012, Dynamics of cognitive change in HIV-infected individuals commencing three different initial antiretroviral regimens: a randomized, controlled study, HIV MEDICINE, Vol: 13, Pages: 245-251, ISSN: 1464-2662
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- Citations: 34
Patel NR, McPhail MJ, Shariff MI, et al., 2012, Biofluid metabonomics using (1)H NMR spectroscopy: the road to biomarker discovery in gastroenterology and hepatology., Expert Rev Gastroenterol Hepatol, Vol: 6, Pages: 239-251
Metabolic profiling or 'metabonomics' is an investigatory method that allows metabolic changes associated with the presence of an underlying pathological process to be investigated. Various biofluids can be utilized in the process but urine, serum and fecal extract are most pertinent to the investigation of gastrointestinal and hepatological disease. Nuclear magnetic resonance spectroscopy-based metabonomic research has the potential to generate novel noninvasive diagnostic tests, based on biomarkers of disease, which are simple and cost effective yet retain high sensitivity and specificity characteristics. The process involves a number of key steps, including sample collection, data acquisition, chemometric techniques and, finally, validation. This technique-driven review aims to demystify the metabonomics pathway, while also illustrating the potential of this technique with recent examples of its application in hepato-gastroenterological disease.
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