Imperial College London
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ProfessorSimonTaylor-Robinson

Faculty of Engineering, Department of Electrical and Electronic Engineering

Visiting Professor
 
 
 
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s.taylor-robinson

 
 
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Location

 

Electrical EngineeringSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cox:2016:10.3748/wjg.v22.i16.4191,
author = {Cox, IJ and Aliev, AE and Crossey, MM and Dawood, M and Al-Mahtab, M and Akbar, SM and Rahman, S and Riva, A and Williams, R and Taylor-Robinson, SD},
doi = {10.3748/wjg.v22.i16.4191},
journal = {World Journal of Gastroenterology},
pages = {4191--4200},
title = {Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: a biomarker corroboration study},
url = {http://dx.doi.org/10.3748/wjg.v22.i16.4191},
volume = {22},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC (39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance (NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis (PCA) and orthogonal partial least squared discriminant analysis (OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLS-DA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance (ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the Mann-Whitney U test was used to compare metabolite levels depending on hepatitis B e-antigen (HBeAg) status and treatment with anti-viral therapy. A Benjamini-Hochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05. RESULTS: There were significant differences in age (P < 0.001), weight (P < 0.001), and body mass index (P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase (ALT) was significantly higher in the HCC group compared to controls (P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group (P = 0.004). A three-factor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, cr
AU  - Cox,IJ
AU  - Aliev,AE
AU  - Crossey,MM
AU  - Dawood,M
AU  - Al-Mahtab,M
AU  - Akbar,SM
AU  - Rahman,S
AU  - Riva,A
AU  - Williams,R
AU  - Taylor-Robinson,SD
DO  - 10.3748/wjg.v22.i16.4191
EP  - 4200
PY  - 2016///
SN  - 1007-9327
SP  - 4191
TI  - Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: a biomarker corroboration study
T2  - World Journal of Gastroenterology
UR  - http://dx.doi.org/10.3748/wjg.v22.i16.4191
UR  - http://hdl.handle.net/10044/1/32449
VL  - 22
ER  -
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