Imperial College London
Alternate

Professor Xiao Yun Xu

Faculty of Engineering, Department of Chemical Engineering

Professor, Biofluid Mechanics & Director of Graduate School
 
 
 
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Contact

 

yun.xu Website

 
 
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Location

 

407ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhu:2021:10.1038/s41598-021-91079-5,
author = {Zhu, Y and Mirsadraee, S and Asimakopoulos, G and Gambaro, A and Rosendahl, U and Pepper, J and Xu, X},
doi = {10.1038/s41598-021-91079-5},
journal = {Scientific Reports},
title = {Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair},
url = {http://dx.doi.org/10.1038/s41598-021-91079-5},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Type A aortic dissection (TAAD) involves the ascending aorta or the arch. Acute TAAD usually requires urgent replacement of the ascending aorta. However, a subset of these patients develops aortic rupture due to further dilatation of the residual dissected aorta. There is currently no reliable means to predict the risk of dilatation following TAAD repair. In this study, we performed a comprehensive morphological and hemodynamic analysis for patients with and without progressive aortic dilatation following surgical replacement of the ascending aorta. Patient-specific models of repaired TAAD were reconstructed from post-surgery computed tomography images for detailed computational fluid dynamic analysis. Geometric and hemodynamic parameters were evaluated and compared between patients with stable aortic diameters (N = 9) and those with aortic dilatation (N = 8). Our results showed that the number of re-entry tears and true/false lumen pressure difference were significantly different between the two groups. Patients with progressive aortic dilatation had higher luminal pressure difference (6.7 [4.6, 10.9] vs. 0.9 [0.5, 2.3] mmHg; P = 0.001) and fewer re-entry tears (1.5 [1, 2.8] vs. 5 [3.3, 7.5]; P = 0.02) compared to patients with stable aortic diameters, suggesting that these factors may serve as potential predictors of aneurysmal dilatation following surgical repair of TAAD.
AU  - Zhu,Y
AU  - Mirsadraee,S
AU  - Asimakopoulos,G
AU  - Gambaro,A
AU  - Rosendahl,U
AU  - Pepper,J
AU  - Xu,X
DO  - 10.1038/s41598-021-91079-5
PY  - 2021///
SN  - 2045-2322
TI  - Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-91079-5
UR  - http://hdl.handle.net/10044/1/89878
VL  - 11
ER  -
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