Imperial College London
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DR YUTONG SAMUEL CAI

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

yutong.cai

 
 
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Location

 

155Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jacquemin:2015:10.1289/ehp.1408206.,
author = {Jacquemin, B and Siroux, V and Sanchez, M and Carsin, AE and Schikowski, T and Adam, M and Bellisario, V and Buschka, A and Bono, R and Brunekreef, B and Cai, Y and Cirach, M and Clavel-Chapelon, F and Declercq, C and Marco, RD and Nazelle, AD and Ducret-Stich, RE and Ferretti, VV and Gerbase, MW and Hardy, R and Heinrich, J and Janson, C and Jarvis, D and Kanaani, ZA and Keidel, D and Kuh, D and Moual, NL and Nieuwenhuijsen, MJ and Marcon, A and Modig, L and Pin, I and Rochat, T and Schindler, C and Sugiri, D and Stempfelet, M and Temam, S and Tsai, MY and Varraso, R and Vienneau, D and Vierkotter, A and Hansell, AL and Kramer, U and Probst-Hensch, NM and Sunyer, J and Kunzli, N and Kauffmann, F},
doi = {10.1289/ehp.1408206.},
journal = {Environmental Health Perspectives},
pages = {613--621},
title = {Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE)},
url = {http://dx.doi.org/10.1289/ehp.1408206.},
volume = {123},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: To investigate the association between air pollution and adult onset asthma. METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter assessed for 17,909 participants through ESCAPE land-use regression models, and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted on age, sex, overweight, education and smoking and included city/area within each cohort as a random effect. RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for NO2, (adjusted OR = 1.10; 95% CI: 0.99, 1.21 per 10 mug/m3; p=0.10) and NOx (1.04; 95% CI: 0.99, 1.08 per 20 mug/m3; p=0.08). Non-significant positive associations were estimated for PM10 (1.04; 95% CI: 0.88, 1.23 per 10 mug/m3), PM2.5 (1.04; 95% CI: 0.88, 1.23 per 5 mug/m3), PM2.5absorbance (1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (1.10; 95% CI: 0.93, 1.30 per four million vehicles x m/day on major roads in a 100m buffer) and traffic intensity (1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A non-significant negative association was estimated for PMcoarse (0.98; 95% CI: 0.87, 1.14 per 5 mug/m3). CONCLUSIONS: Results are suggestive of a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (versus residential exposure assessment only) and phenotypic characterization is needed.
AU  - Jacquemin,B
AU  - Siroux,V
AU  - Sanchez,M
AU  - Carsin,AE
AU  - Schikowski,T
AU  - Adam,M
AU  - Bellisario,V
AU  - Buschka,A
AU  - Bono,R
AU  - Brunekreef,B
AU  - Cai,Y
AU  - Cirach,M
AU  - Clavel-Chapelon,F
AU  - Declercq,C
AU  - Marco,RD
AU  - Nazelle,AD
AU  - Ducret-Stich,RE
AU  - Ferretti,VV
AU  - Gerbase,MW
AU  - Hardy,R
AU  - Heinrich,J
AU  - Janson,C
AU  - Jarvis,D
AU  - Kanaani,ZA
AU  - Keidel,D
AU  - Kuh,D
AU  - Moual,NL
AU  - Nieuwenhuijsen,MJ
AU  - Marcon,A
AU  - Modig,L
AU  - Pin,I
AU  - Rochat,T
AU  - Schindler,C
AU  - Sugiri,D
AU  - Stempfelet,M
AU  - Temam,S
AU  - Tsai,MY
AU  - Varraso,R
AU  - Vienneau,D
AU  - Vierkotter,A
AU  - Hansell,AL
AU  - Kramer,U
AU  - Probst-Hensch,NM
AU  - Sunyer,J
AU  - Kunzli,N
AU  - Kauffmann,F
DO  - 10.1289/ehp.1408206.
EP  - 621
PY  - 2015///
SN  - 1552-9924
SP  - 613
TI  - Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE)
T2  - Environmental Health Perspectives
UR  - http://dx.doi.org/10.1289/ehp.1408206.
UR  - http://hdl.handle.net/10044/1/25457
VL  - 123
ER  -
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