Imperial College London
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ProfessorAnneLingford-Hughes

Faculty of Medicine, Department of Brain Sciences

Chair in Addiction Biology
 
 
 
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Contact

 

+44 (0)20 7594 8682anne.lingford-hughes Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Daglish:2001,
author = {Daglish, MR and Weinstein, A and Malizia, AL and Wilson, S and Melichar, JK and Britten, S and Brewer, C and Lingford-Hughes, A and Myles, JS and Grasby, P and Nutt, DJ},
journal = {Am.J.Psychiatry},
pages = {1680--1686},
title = {Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects},
url = {pm:11579002},
volume = {158},
year = {2001}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: The brain circuitry of opiate craving was investigated with positron emission tomography (PET) imaging of regional cerebral blood flow (rCBF). METHOD: Twelve abstinent opiate-dependent subjects listened to audiotaped autobiographical scripts of an episode of craving and a neutral episode while undergoing a PET scan with the tracer [(15)O]H(2)O. Statistical parametric mapping was used to analyze the PET images of rCBF changes. RESULTS: Comparison of the drug-related and neutral stimulus conditions revealed activation of rCBF in the left medial prefrontal and left anterior cingulate cortices and deactivation in the occipital cortex in response to the drug-related stimulus. A further statistical parametric mapping analysis with a subjective rating of craving as a covariate showed a positive association of between craving and rCBF in the left orbitofrontal cortex. CONCLUSIONS: The patterns of cerebral activation reflect the different brain regions mediating the salience of opiate-related stimuli and the subjective experience of craving for opiates
AU  - Daglish,MR
AU  - Weinstein,A
AU  - Malizia,AL
AU  - Wilson,S
AU  - Melichar,JK
AU  - Britten,S
AU  - Brewer,C
AU  - Lingford-Hughes,A
AU  - Myles,JS
AU  - Grasby,P
AU  - Nutt,DJ
EP  - 1686
PY  - 2001///
SP  - 1680
TI  - Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects
T2  - Am.J.Psychiatry
UR  - pm:11579002
VL  - 158
ER  -
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