Publications

BibTex format

@article{Gardiner:2018:10.1111/dom.13359,
author = {Gardiner, JV and Ma, Y and Ratnasabapathy, R and Izzi-Engbeaya, CN and Nguyen-Tu, M-S and Richardson, E and Hussain, S and De, Backer I and Holton, C and Norton, M and Carrat, G and Schwappach, B and Rutter, G and Dhillo, W},
doi = {10.1111/dom.13359},
journal = {Diabetes, Obesity and Metabolism},
pages = {2246--2254},
title = {Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis},
url = {http://dx.doi.org/10.1111/dom.13359},
volume = {20},
year = {2018}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AimsGlucokinase (GK) serves as a glucose sensor in several tissues including glucosesensitive neurons of the arcuate nucleus within the hypothalamus. We have previously demonstrated a role for arcuate GK in the regulation of food and glucose intake. However, its role in the regulation of glucose homeostasis is less clear. We therefore sought to investigate the role of arcuate GK in the regulation of glucose homeostasis.Materials and MethodsRecombinant adenoassociated virus expressing either GK or an antisense GK construct was used to alter GK activity specifically in the hypothalamic arcuate nucleus. GK activity in this nucleus was also increased by stereotactic injection of the GK activator, compound A. The effect of altered arcuate nucleus GK activity on glucose homeostasis was subsequently investigated using glucose and insulin tolerance tests.ResultsIncreased GK activity specifically within the arcuate nucleus increased insulin secretion and improved glucose tolerance in rats during oral glucose tolerance tests. Decreased GK activity in this nucleus reduced insulin secretion and increased glucose levels during the same tests. Insulin sensitivity was not affected in either case. The effect of arcuate nucleus glucokinase was maintained in a model of type 2 diabetes.ConclusionsThese results demonstrate a role for arcuate nucleus GK in systemic glucose homeostasis.
AU  - Gardiner,JV
AU  - Ma,Y
AU  - Ratnasabapathy,R
AU  - Izzi-Engbeaya,CN
AU  - Nguyen-Tu,M-S
AU  - Richardson,E
AU  - Hussain,S
AU  - De,Backer I
AU  - Holton,C
AU  - Norton,M
AU  - Carrat,G
AU  - Schwappach,B
AU  - Rutter,G
AU  - Dhillo,W
DO  - 10.1111/dom.13359
EP  - 2254
PY  - 2018///
SN  - 1462-8902
SP  - 2246
TI  - Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis
T2  - Diabetes, Obesity and Metabolism
UR  - http://dx.doi.org/10.1111/dom.13359
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/dom.13359
UR  - http://hdl.handle.net/10044/1/59987
VL  - 20
ER  -

Download

ProfessorGuyRutter

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)