Imperial College London
Alternate

ProfessorPaulElliott

Faculty of Medicine, School of Public Health

Chair in Epidemiology and Public Health Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3328p.elliott Website

 
 
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Assistant

 

Miss Jennifer Wells +44 (0)20 7594 3328

 
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Location

 

154Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mustafa:2022:10.1101/2022.11.10.22282180,
author = {Mustafa, R and Mens, MMJ and van, Hilten A and Huang, J and Roshchupkin, G and Huan, T and Broer, L and Elliott, P and Levy, D and Ikram, MA and Evangelou, M and Dehghan, A and Ghanbari, M},
doi = {10.1101/2022.11.10.22282180},
title = {An atlas of genetic regulation and disease associations of microRNAs},
url = {http://dx.doi.org/10.1101/2022.11.10.22282180},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Identification of genetic variants influencing the transcription of miRNAs can provide an understanding of their genetic regulation and implication in human disease. Here we present genome-wide association studies of 2,083 plasma circulating miRNAs measured by next-generation sequencing in 2,178 participants of the Rotterdam Study to identify miRNA-expression quantitative trait loci (miR-eQTLs). We report 4,310 cis- and trans-miR-eQTLs for 64 miRNAs that have been replicated across independent studies. Many of these miR-eQTLs overlap with gene expression, protein, and metabolite-QTLs and with disease-associated variants. The consequences of perturbation in miRNA transcription on a wide range of clinical conditions are systematically investigated in phenome-wide association studies, with their causality tested using Mendelian randomization. Integration of genomics and miRNAs enables interrogation of the genetic architecture of miRNAs, revealing their clinical importance, and providing valuable resources for future studies of miRNAs in human disease.</jats:p>
AU  - Mustafa,R
AU  - Mens,MMJ
AU  - van,Hilten A
AU  - Huang,J
AU  - Roshchupkin,G
AU  - Huan,T
AU  - Broer,L
AU  - Elliott,P
AU  - Levy,D
AU  - Ikram,MA
AU  - Evangelou,M
AU  - Dehghan,A
AU  - Ghanbari,M
DO  - 10.1101/2022.11.10.22282180
PY  - 2022///
TI  - An atlas of genetic regulation and disease associations of microRNAs
UR  - http://dx.doi.org/10.1101/2022.11.10.22282180
ER  -
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