Imperial College London
Alternate

Professor Sir Roy Anderson FRS, FMedSci

Faculty of Medicine, School of Public Health

Professor in Infectious Disease Epidemiology
 
 
 
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Contact

 

roy.anderson Website

 
 
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Assistant

 

Mrs Clare Mylchreest +44 (0)7766 331 301

 
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Location

 

LG35Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Anderson:2014:10.1098/rstb.2013.0435,
author = {Anderson, R and Truscott, J and Hollingsworth, TD},
doi = {10.1098/rstb.2013.0435},
journal = {Philosophical Transactions of the Royal Society B: Biological Sciences},
title = {The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths},
url = {http://dx.doi.org/10.1098/rstb.2013.0435},
volume = {369},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A combination of methods, including mathematical model construction, demographic plus epidemiological data analysis and parameter estimation, are used to examine whether mass drug administration (MDA) alone can eliminate the transmission of soil-transmitted helminths (STHs). Numerical analyses suggest that in all but low transmission settings (as defined by the magnitude of the basic reproductive number, R0), the treatment of pre-school-aged children (pre-SAC) and school-aged children (SAC) is unlikely to drive transmission to a level where the parasites cannot persist. High levels of coverage (defined as the fraction of an age group effectively treated) are required in pre-SAC, SAC and adults, if MDA is to drive the parasite below the breakpoint under which transmission is eliminated. Long-term solutions to controlling helminth infections lie in concomitantly improving the quality of the water supply, sanitation and hygiene (WASH). MDA, however, is a very cost-effective tool in long-term control given that most drugs are donated free by the pharmaceutical industry for poor regions of the world. WASH interventions, by lowering the basic reproductive number, can facilitate the ability of MDA to interrupt transmission.
AU  - Anderson,R
AU  - Truscott,J
AU  - Hollingsworth,TD
DO  - 10.1098/rstb.2013.0435
PY  - 2014///
SN  - 1471-2970
TI  - The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths
T2  - Philosophical Transactions of the Royal Society B: Biological Sciences
UR  - http://dx.doi.org/10.1098/rstb.2013.0435
UR  - http://hdl.handle.net/10044/1/28760
VL  - 369
ER  -
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