We are looking to recruit an enthusiastic, curious and highly-motivated scientist to join the Chromatin & Development group, headed by Dr Michelle Percharde The Chromatin & Development group is a recently-established team focused on understanding the molecular events surrounding cell fate choices during early development. Our recent research indicates that Transposable Elements (TEs) have important, undiscovered roles during development, and...
Job listing information
- Reference MED01197
- Date posted 15 April 2019
- Closing date 16 May 2019
We are looking to recruit an enthusiastic, curious and highly-motivated scientist to join the Chromatin & Development group, headed by Dr Michelle Percharde
The Chromatin & Development group is a recently-established team focused on understanding the molecular events surrounding cell fate choices during early development. Our recent research indicates that Transposable Elements (TEs) have important, undiscovered roles during development, and projects in the lab include uncovering how TE regulation is important during embryogenesis. We are furthermore investigating how unrestrained TE expression may contribute to cases of disease. To answer these questions, we routinely use mouse and human embryonic stem cells (ESCs) and mouse embryos as models, adopting a combination of genome-wide techniques, CRISPR/Cas9 technology, high-resolution microscopy, biochemistry and molecular embryology approaches to probe gene and TE function. Visit www.perchardelab.com and https://lms.mrc.ac.uk/research-group/chromatin-and-development/ for more information.
Duties and responsibilities
- To think independently, design experiments and conduct high-quality research in line with the agreed project aims
- To critically analyse and present data, ensuring reliability, reproducibility and statistical robustness.
- To keep abreast of current published research and preprints, and integrate findings into own project ideas and techniques
- To develop new techniques and protocols as necessary for the project
- To attend all lab and related research meetings, and to present work when required
- To assist others and co-supervise students when required
- To attend and contribute to journal clubs and seminar presentations
- To present data at national and international meetings (where and when appropriate)
- To interact and collaborate with researchers in related projects, and take an active role in the academic life of the Institute of Clinical Sciences (ICS)
- To write-up work for publication in peer-reviewed journals, and 1assist with data and writing of grant proposals, when necessary
- To form good working relationships with other members of the group, as well as internal and external collaborators.
- To contribute to the development and maintenance of the group’s experimental infrastructure as appropriate.
- To help with the daily running of the lab by assisting with general lab duties as required.
Successful candidates must have the following essential attributes:
- PhD degree or equivalent in a relevant biological/biomedical discipline (or be in the final stages of completing one)
- One or more first-author publications in a peer-reviewed internationally recognized journal (being submitted or published)
- Strong background in epigenetics, developmental biology and/or gene regulation
- Significant research experience working with mammalian biological systems (e.g. mammalian tissue culture, ESCs, mouse models)
- Extensive practical experience in biochemical and molecular biology techniques (e.g. ChIP, qRT-PCR, western blotting, cloning)
The ideal applicant should have at least one or more of these desirable qualities:
- Use of mus musculus as an experimental model in development (e.g. embryo manipulation)
- Expertise in the culture of mouse and/or human ESCs
- Interest and previous background in studying protein-protein interactions (e.g. proteomics, mass-spec, biochemistry)
- Experience with genome-wide experiments (RNA-seq, ChIP-seq, ATAC-seq) and/or bioinformatic analysis
- Proven interest in RNA or TE biology in developmental contexts
Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £34,397- £37,486 per annum.
Please contact Dr Michelle Percharde with any informal enquiries: email@example.com
For technical issues when applying online please email firstname.lastname@example.org
Interviews will be held between 3 - 5 June 2019
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