Research Associate in Circadian Biology, UK DRI

Job summary

The UK DRI is seeking an outstanding Research Associate interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth.  The ideal candidate will be passionate about tackling big problems and be ready to try out high-risk, high-payoff projects. The UK Dementia Research Institute (UK DRI) at Imperial has been established to address a medical research area of the highest importance...

Job listing information

  • Reference MED01436
  • Date posted 12 November 2019
  • Closing date 5 January 2020

Job description

Job summary

The UK DRI is seeking an outstanding Research Associate interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth.  The ideal candidate will be passionate about tackling big problems and be ready to try out high-risk, high-payoff projects.

The UK Dementia Research Institute (UK DRI) at Imperial has been established to address a medical research area of the highest importance and future impact. As one of seven national centres of excellence embedded in major UK universities, we intend to transform the diagnosis, treatment and care of people with dementias.  The Medical Research Council and charity partners the Alzheimer's Society and Alzheimer’s Research UK have invested £290m in fulfilment of the ambition identified in the Prime Minister's 2020 Challenge on Dementia.

The fellowship programme of Dr Marco Brancaccio is focused on defining the mechanisms driving circadian dysfunction in the early stages of Alzheimer’s disease (AD). Sleep and circadian disturbances have been recently associated with the earliest preclinical manifestations of AD, in both humans and animal models of the disease. We will investigate the molecular, cellular and circuit mechanisms underlying this association, the genetic and environmental factors driving circadian dysfunction and their specific role in the AD pathogenic cascade. The long-term goal of this project is the development of novel therapeutic approaches aimed at recruiting circadian clocks in the brain for the prevention/ early intervention of AD.

 

Duties and responsibilities

You will be expected to help to define specific research programmes and undertake these in conjunction with colleagues in multi-disciplinary teams. Considerable independence is expected, with anticipation of a growing role in leadership of the research.  In addition, you will be expected to submit publications to refereed journals and to join in attracting external research funding.         

There will be opportunities for supervision of students. Experience in other teaching roles, including lecturing, will be enabled as part of the broad range of career development opportunities that Imperial College makes available to its post-doctoral research staff.

Essential requirements

A PhD (or being in the final stages of completion) in neuroscience, biological sciences or a closely related discipline, or equivalent research, industrial or commercial experience is required. Knowledge of in vivo/ in vitro microscopy and imaging software and of research methods and statistical procedures is also needed.

Practical experience in viral vector design and production (AAVs, LVs), IPSCs cultures, next generation RNA sequencing and other -OMICS techniques, live imaging, stereotaxic surgery and mouse behaviour (cognitive tests, sleep and circadian function) will be considered as an advantage. Experience in circadian and sleep research is also an advantage, but it is not strictly required.

Further information

Please note this is a re-advertisement; previous applicants need not apply.

The contract is offered full time, initially for a fixed term of two years.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.

Applicants are strongly encouraged to contact Dr Marco Brancaccio (m.brancaccio@imperial.ac.uk) for informal discussion about the role.  

Interviews are expected to be held during the second half of October.

For more information about the UK DRI at Imperial, please visit:

http://www.imperial.ac.uk/dementia-research-institute

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.