Research Assistant in Haematopoietic Stem Cell Biology

Job summary

The Haematopoietic Stem Cell Niche Laboratory, led by Dr Tiago C. Luis is seeking to recruit a Research Assistant to join its team in the South Kensington Campus of Imperial College London. Research in the laboratory focuses on understanding the molecular mechanisms by which the bone marrow niche regulates haematopoietic stem cells (HSC) function in the maintenance of blood cells homeostasis and the development of haematological malignancies....

Job listing information

  • Reference NAT00635
  • Date posted 17 January 2020
  • Closing date 16 February 2020

Job description

Job summary

The Haematopoietic Stem Cell Niche Laboratory, led by Dr Tiago C. Luis is seeking to recruit a Research Assistant to join its team in the South Kensington Campus of Imperial College London.

Research in the laboratory focuses on understanding the molecular mechanisms by which the bone marrow niche regulates haematopoietic stem cells (HSC) function in the maintenance of blood cells homeostasis and the development of haematological malignancies.

You will work on an exciting project aimed at understanding how the niche is remodelled in different situations of perturbed haematopoiesis and, at decoding the molecular cross talk between HSCs and their niche in these processes. This is a multidisciplinary project involving the use of different in vivo mouse models, which will be analysed by cutting edge multi-parameter flow cytometry, gene expression techniques (including multiplex qPCR and RNA sequencing) and imaging of the bone marrow niche. For more details on our research please see the laboratory web site.

The Department of Life Sciences (DoLS) at Imperial College London, embraces the full breadth of modern life sciences activity, which is organized in 12 research themes. DoLS is located on 2 campuses at South Kensington and Silwood Park and is one of the largest life sciences groups in Europe. DoLS was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 Times Higher Education, scoring 100% on our environment.  

Duties and responsibilities

You will be responsible for running experiments and day-to-day project management and development. The project will involve a high degree of teamwork, interdisciplinary research and flexibility in developing and managing complex and demanding experimental protocols and data sets.

Your main duties are described below:

  • To be pro-active in planning and conducting the research work and to perform data analysis, with appropriate supervision;
  • To ensure the validity and reliability of data at all times;
  • To keep good records of all experiments and data derived from them;
  • To perform research that fulfils the requirements of the grant objective;
  • To perform duties associated with support of the research in the laboratory, including various laboratory rotas, resources, inventories and stocks organisation;
  • To present findings to colleagues, collaborators.

Essential requirements

You must hold a master’s degree (or equivalent) in biology, biomedical sciences, biochemistry or a related field. Experience with in vivo mouse models is essential. Experience with either basic molecular techniques for gene expression analysis or flow cytometry is also essential.Successful completion of PIL-ABC or Module K training will be an advantage.

You must have excellent written, verbal communication and interpersonal skills, excellent laboratory and organisational skills. The ability to prioritise your work in response to deadlines, to use your initiative and being able to work independently as well as part of the team are all essential. A track record in quantitative analysis of complex datasets will be also be an advantage.

You must be able to demonstrate:

Experience with:

  • In vivo mouse models;
  • Basic molecular biology and gene expression analysis such as RT-qPCR;
  • Flow Cytometry;

Knowledge of:

  • Stem cell biology and/or haematopoiesis;
  • Research methods and data/statistical analysis in this field;

Further information

For more information visit the laboratory web site. Should you require any further details on the role please contact Dr Tiago Luis (t.luis@imperial.ac.uk).

This is a full-time post, funded for a fixed term period of one year from March 1st, 2020, with opportunity for extension, subject to funding availability. Candidates who wish to enrol in a PhD program at a later stage are strongly encouraged to apply.

For technical issues when applying online please email: recruitment@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

 

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.