Imperial College London

DrBarrySeemungal

Faculty of MedicineDepartment of Medicine

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 3311 7042b.seemungal

 
 
//

Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
//

Location

 

10L17Lab BlockCharing Cross Campus

//

Summary

 

Publications

Publication Type
Year
to

93 results found

Seemungal B, Klein JL, 1996, Respiratory grey case., Int J STD AIDS, Vol: 7, ISSN: 0956-4624

JOURNAL ARTICLE

Steuer A, Seemungal BM, Grenfell A, 1996, A hot ankle., Lancet, Vol: 347, ISSN: 0140-6736

JOURNAL ARTICLE

Elliott P, Seemungal BM, Wallis DI, 1990, Antagonism of the effects of 5-hydroxytryptamine on the rabbit isolated vagus nerve by BRL 43694 and metoclopramide., Naunyn Schmiedebergs Arch Pharmacol, Vol: 341, Pages: 503-509, ISSN: 0028-1298

Depolarization and reduction in the C fibre compound action potential (C spike) in response to 5-HT were recorded simultaneously from rabbit isolated vagus nerve. 5-HT (0.1-100 mumol/l) was applied cumulatively and EC50 and IC50 values measured from individual concentration-response curves. Blockade of 5-HT responses by the 3-indazole carboxamide, BRL 43694, was investigated and compared with the blocking action of metoclopramide. BRL 43694 was a selective antagonist of 5-HT responses. A concentration of 10 nmol/l BRL 43694, which nearly abolished the depolarization and reduction of the C spike evoked by 5-HT (100 mumol/l), had no effect on similar responses evoked by DMPP (100 mumol/l) or GABA (100 mumol/l). Blockade of 5-HT responses by BRL 43694 (0.3 nmol/l) was slow in onset, a plateau blockade occurring after equilibrium of tissue with antagonist for 2 to 3 h. Metoclopramide induced a blockade of rapid onset. The maximal blockade was apparent within 30 min of application. Full recovery in the responsiveness of the tissue to 5-HT was observed within 30 min of washing out metoclopramide. BRL 43694 at concentrations of 0.3, 1, 3 and 10 nmol/l caused a progressive rightward shift of the concentration-response curves to 5-HT. At the highest concentration of antagonist, there was some depression of the maximal 5-HT response. The apparent pA2 estimated from the Schild equation was 10.03 +/- 0.09 (mean +/- SEM, n = 20) against 5-HT depolarization and 10.31 +/- 0.1 against C spike reduction. Schild plots had slopes not significantly different from 1.0.(ABSTRACT TRUNCATED AT 250 WORDS)

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00341396&limit=30&person=true&page=4&respub-action=search.html