Imperial College London

New Publication in Organic Letters


Multi-Facial Alpha Helix Mimetics generated from simple monomer building blocks

Our new publication in Organic Letters is now out!

Our new paper entitled 'Design, Synthesis and Conformational Analysis of Oligobenzanilides as Multi-Facial alpha-Helix Mimetics' is now out in Organic Letters:

In this paper the design, synthesis, and conformational analysis of an oligobenzanilide helix mimetic scaffold capable of simultaneous mimicry of two faces of an α-helix is reported. The synthetic methodology provides access to diverse monomer building blocks amenable to solid-phase assembly in just four synthetic steps. The conformational flexibility of model dimers was investigated using a combination of solid and solution state methodologies supplemented with DFT calculations. The lack of noncovalent constraints allows for significant conformational plasticity in the scaffold, thus permitting it to successfully mimic residues ii+2, i+4, i+6, i+7, and i+9 of a canonical α-helix.

The synthetic work and conformational analysis was performed by Dr Theo Flack during his PhD and DFT calculations were performed in collaboration with Dr Charles Romain. Crysallography and NMR assistance were provided by Andrew White and Pete Haycock. Congratulations to all involved!



Anna Barnard

Anna Barnard
Department of Chemistry

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