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@article{Sabnis:2025:10.1016/j.celrep.2025.116456,
author = {Sabnis, A and Figueroa, W and Santos-López, A and Bradshaw, J and Kee, M-JCY and Chen, J and San, Millán Á and Penades, J},
doi = {10.1016/j.celrep.2025.116456},
journal = {Cell reports},
title = {Non-conjugative plasmids limit their mobility to persist in nature},
url = {http://dx.doi.org/10.1016/j.celrep.2025.116456},
volume = {44},
year = {2025}
}
TY - JOUR
AB - Plasmids are mobile genetic elements that disseminate beneficial genes, such as those conferring antibiotic resistance, but the evolutionary forces shaping their distribution remain unclear. This study challenges the idea that non-conjugative plasmids evolved for high-frequency spread. Using Staphylococcus aureus as a model, we found these plasmids lack key DNA sequences (“pac” or “cos” sites) essential for efficient phage-mediated transduction, despite such sequences not being costly. While S. aureus plasmids can evolve to enhance phage-mediated mobility by incorporating phage DNA, this strategy proves detrimental. In mixed populations, low plasmid transfer enables plasmids to coexist and protect host bacteria and neighbours from threats. However, increased movement reduces plasmid diversity, eroding protective benefits and leaving populations vulnerable. Our findings indicate plasmids evolve to restrict movement, maintaining diversity and ensuring survival against threats like antibiotics and phages. This balance explains why plasmid mobility remains low in nature, despite their potential for rapid gene transfer.
AU - Sabnis,A
AU - Figueroa,W
AU - Santos-López,A
AU - Bradshaw,J
AU - Kee,M-JCY
AU - Chen,J
AU - San,Millán Á
AU - Penades,J
DO - 10.1016/j.celrep.2025.116456
PY - 2025///
SN - 2211-1247
TI - Non-conjugative plasmids limit their mobility to persist in nature
T2 - Cell reports
UR - http://dx.doi.org/10.1016/j.celrep.2025.116456
UR - https://www.sciencedirect.com/science/article/pii/S2211124725012276
VL - 44
ER -