BibTex format
@article{Lonjou:2000:10.1073/pnas.97.20.10942,
author = {Lonjou, C and Barnes, K and Chen, H and Cookson, WOCM and Deichmann, KA and Hall, IP and Holloway, JW and Laitinen, T and Palmer, LJ and Wjst, M and Morton, NE},
doi = {10.1073/pnas.97.20.10942},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
pages = {10942--10947},
title = {A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG)},
url = {http://dx.doi.org/10.1073/pnas.97.20.10942},
volume = {97},
year = {2000}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The central problem of complex inheritance is to map oligogenes for disease susceptibility, integrating linkage and association over samples that differ in several ways. Combination of evidence over multiple samples with 1,037 families supports loci contributing to asthma susceptibility in the cytokine region on 5q [maximum logarithm of odds (lod) = 2.61 near IL-4], but no evidence for atopy. The principal problems with retrospective collaboration on linkage appear to have been solved, providing far more information than a single study. A multipoint lod table evaluated at commonly agreed reference loci is required for both collaboration and metaanalysis, but variations in ascertainment, pedigree structure, phenotype definition, and marker selection are tolerated. These methods are invariant with statistical methods that increase the power of lods and are applicable to all diseases, motivating collaboration rather than competition. In contrast to linkage, positional cloning by allelic association has yet to be extended to multiple samples, a prerequisite for efficient combination with linkage and the greatest current challenge to genetic epidemiology.
AU - Lonjou,C
AU - Barnes,K
AU - Chen,H
AU - Cookson,WOCM
AU - Deichmann,KA
AU - Hall,IP
AU - Holloway,JW
AU - Laitinen,T
AU - Palmer,LJ
AU - Wjst,M
AU - Morton,NE
DO - 10.1073/pnas.97.20.10942
EP - 10947
PY - 2000///
SN - 0027-8424
SP - 10942
TI - A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG)
T2 - Proceedings of the National Academy of Sciences of the United States of America
UR - http://dx.doi.org/10.1073/pnas.97.20.10942
VL - 97
ER -