In this section
@article{Palmer:2000:10.1164/ajrccm.161.6.9805104,
author = {Palmer, LJ and Burton, PR and Faux, JA and James, AL and Musk, AW and Cookson, WO},
doi = {10.1164/ajrccm.161.6.9805104},
journal = {Am J Respir Crit Care Med},
pages = {1836--1843},
title = {Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness.},
url = {http://dx.doi.org/10.1164/ajrccm.161.6.9805104},
volume = {161},
year = {2000}
}
TY - JOUR
AB - Elevated serum Immunoglobulin E (IgE) levels and increased airway responsiveness (AR) are correlated traits that are characteristic of asthma. It is not known to what extent these traits arise from distinct or shared genetic determinants. We investigated the genetic and environmental components of variance of serum total and specific IgE levels and AR in an Australian population-based sample of 232 Caucasian nuclear families. The inter-relationships of the genetic determinants of these traits were also investigated. Log(e) total serum IgE levels had a narrow-sense heritability (h(2)(N)) of 47.3% (SE = 10.0%). Specific serum IgE levels against house dust mite and timothy grass, measured as a RAST Index, ad a h(2)(N) of 33.8% (SE = 7.3%). AR, quantified by the log(e) dose-response slope to methacholine (DRS), had a h(2)(N) of 30.0% (SE = 12.3%). Extended modeling demonstrated an approximate 70% overlap in the genetic determinants of total and specific serum IgE levels. The genetic determinants of serum IgE levels and AR exhibited less than 30% sharing. These data are consistent with the existence of multiple genetic determinants of the pathophysiologic traits associated with asthma, and suggest that AR is genetically distinct from atopy. These results have implications for gene discovery programs.
AU - Palmer,LJ
AU - Burton,PR
AU - Faux,JA
AU - James,AL
AU - Musk,AW
AU - Cookson,WO
DO - 10.1164/ajrccm.161.6.9805104
EP - 1843
PY - 2000///
SN - 1073-449X
SP - 1836
TI - Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness.
T2 - Am J Respir Crit Care Med
UR - http://dx.doi.org/10.1164/ajrccm.161.6.9805104
UR - https://www.ncbi.nlm.nih.gov/pubmed/10852754
VL - 161
ER -
For any enquiries about the Fungal Science Network at Imperial, please contact: