BibTex format
@article{Palmer:1998:10.1164/ajrccm.158.6.9804037,
author = {Palmer, LJ and Daniels, SE and Rye, PJ and Gibson, NA and Tay, GK and Cookson, WO and Goldblatt, J and Burton, PR and LeSöuef, PN},
doi = {10.1164/ajrccm.158.6.9804037},
journal = {Am J Respir Crit Care Med},
pages = {1825--1830},
title = {Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children.},
url = {http://dx.doi.org/10.1164/ajrccm.158.6.9804037},
volume = {158},
year = {1998}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations is an important part of the gene discovery process. This study investigated the linkage of microsatellite markers in the 5q and 11q regions to asthma-associated quantitative traits in 121 Australian Caucasian nuclear families. The families were recruited on the basis of a child proband: a cohort of 95 randomly recruited families of unselected probands (n = 442 subjects) and a cohort of 26 families of probands selected on the basis of severe symptomatic asthma (n = 134 subjects). The quantitative traits assessed included serum levels of total IgE and specific IgE to house dust mite and mixed grass, blood eosinophil counts, and the dose-response slope (DRS) of FEV1 to histamine provocation. Multipoint linkage analysis using Haseman-Elston sib-pair methods provided evidence of significant linkage between the chromosome 5q markers and loge total serum IgE levels, specific serum IgE levels, and loge blood eosinophil counts. The chromosome 11q markers showed evidence of significant linkage to specific serum IgE levels. Neither region demonstrated significant linkage to the loge DRS to histamine. Phenotypes were residualized for age and sex. These data are consistent with the existence of loci regulating asthma-associated quantitative traits in both the 5q31-33 and 11q13 chromosomal regions.
AU - Palmer,LJ
AU - Daniels,SE
AU - Rye,PJ
AU - Gibson,NA
AU - Tay,GK
AU - Cookson,WO
AU - Goldblatt,J
AU - Burton,PR
AU - LeSöuef,PN
DO - 10.1164/ajrccm.158.6.9804037
EP - 1830
PY - 1998///
SN - 1073-449X
SP - 1825
TI - Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children.
T2 - Am J Respir Crit Care Med
UR - http://dx.doi.org/10.1164/ajrccm.158.6.9804037
UR - https://www.ncbi.nlm.nih.gov/pubmed/9847274
VL - 158
ER -