In this section
@inbook{Moffatt:2006,
author = {Moffatt, MF and Cookson, WOC},
booktitle = {Genetics of Asthma and Chronic Obstructive Pulmonary Disease},
pages = {223--238},
title = {Fine mapping and whole genome association studies in Asthma and chronic obstructive pulmonary disease},
year = {2006}
}
TY - CHAP
AB - Positional cloning is much more likely to identify novel genetic effects than candidate gene studies. Genetic linkage studies are very powerful for the study of single gene disorders, but have limited power in complex genetic disorders when many genes are likely to be acting and there is no established model for the inheritance of a given disease. Genetic linkage studies in a complex disorder such as Asthma typically give an imprecise signal for the localization of the diseased gene that may extend over tens of megabases of DNA. This is because only a proportion of families will actually be linked to the locus, while others will appear randomly linked and nonlinked. In addition, the proportion of individuals with susceptibility alleles who develop the disease will vary between families (i.e., the alleles will have variable penetrance). For this reason, even highly ambitious genetic linkage studies involving several hundreds of families have often failed to deliver conclusive results.
AU - Moffatt,MF
AU - Cookson,WOC
EP - 238
PY - 2006///
SP - 223
TI - Fine mapping and whole genome association studies in Asthma and chronic obstructive pulmonary disease
T1 - Genetics of Asthma and Chronic Obstructive Pulmonary Disease
ER -
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