In this section
@inbook{Adcock:2006:B0-12-370879-6/00386-0,
author = {Adcock, IM and Ito, K and Caramori, G},
booktitle = {Encyclopedia of Respiratory Medicine Four Volume Set},
doi = {B0-12-370879-6/00386-0},
pages = {243--251},
title = {Transcription Factors: Overview},
url = {http://dx.doi.org/10.1016/B0-12-370879-6/00386-0},
year = {2006}
}
TY - CHAP
AB - The term 'transcription factor' refers to a large family of proteins, which exert transcriptional control via specific interactions with regulatory gene sequences. Here, we provide a summary of the different classes of the transcription factor divided according to their DNA-binding motifs. The modular structure of transcription factors and the presence of distinct interacting domains determine the ability of these factors to associate with each other and with coactivating/repressing proteins. By recruiting transcriptional coactivators, transcription factors can induce changes in chromatin structure enabling gene expression to occur. We use the activation of the Rel transcription factor NF-B and the nuclear receptor GR as examples to indicate some of the intricacies and subtleties of DNA binding, chromatin remodeling, and transcription factor cross-talk. Finally, we review the evidence for the involvement of select transcription factors in allergic and inflammatory diseases of the lung, and how changes in the expression and/or activity of these factors may vary in disease and provide important targets for future drug development.
AU - Adcock,IM
AU - Ito,K
AU - Caramori,G
DO - B0-12-370879-6/00386-0
EP - 251
PY - 2006///
SP - 243
TI - Transcription Factors: Overview
T1 - Encyclopedia of Respiratory Medicine Four Volume Set
UR - http://dx.doi.org/10.1016/B0-12-370879-6/00386-0
ER -
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