In this section
@inbook{Adcock:2006:B0-12-370879-6/00100-9,
author = {Adcock, IM and Hayashi, R and Ito, K and Caramori, G},
booktitle = {Encyclopedia of Respiratory Medicine Volume 1 4},
doi = {B0-12-370879-6/00100-9},
title = {CORTICOSTEROIDS},
url = {http://dx.doi.org/10.1016/B0-12-370879-6/00100-9},
year = {2006}
}
TY - CHAP
AB - Corticosteroids bind to and activate a cytoplasmic glucocorticoid receptor (GR) which exists as several isoforms derived from a single gene product by alternative splicing. The activated glucocorticoid receptor translocates into the nucleus and binds to specific response elements in the promoter regions of anti-inflammatory genes such as lipocortin-1 and secretory leukocyte protease inhibitor. However, the major anti-inflammatory effects of glucocorticoids appear to be due largely to interaction between the activated glucocorticoid receptor and transcription factors, notably nuclear factor kappa B (NF- κB) and activator protein-1, that mediate the expression of inflammatory genes. NF- κB switches on inflammatory genes via a process involving recruitment of transcriptional coactivator proteins and changes in chromatin modifications such as histone acetylation. The interactions between NF- κB and the glucocorticoid receptor result in differing effects on histone modifications and subsequent chromatin remodeling. GR is subjected to posttranslational modifications and these may influence hormone binding and nuclear translocation, alter glucocorticoid receptor interactions and protein half-life. Therapeutically, drugs that enhance glucocorticoid receptor nuclear translocation (long-acting β-agonists) and GR-associated histone deacetylase activity (theophylline) have been shown to be effective add-on therapies. In addition, dissociated glucocorticoids that target NF- κB preferentially have also been successful in the treatment of allergic disease in the skin.
AU - Adcock,IM
AU - Hayashi,R
AU - Ito,K
AU - Caramori,G
DO - B0-12-370879-6/00100-9
PY - 2006///
TI - CORTICOSTEROIDS
T1 - Encyclopedia of Respiratory Medicine Volume 1 4
UR - http://dx.doi.org/10.1016/B0-12-370879-6/00100-9
ER -
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