In this section
@article{Moffatt:1997:10.1007/s002510050266,
author = {Moffatt, MF and Schou, C and Faux, JA and Cookson, WO},
doi = {10.1007/s002510050266},
journal = {Immunogenetics},
pages = {226--230},
title = {Germline TCR-A restriction of immunoglobulin E responses to allergen.},
url = {http://dx.doi.org/10.1007/s002510050266},
volume = {46},
year = {1997}
}
TY - JOUR
AB - Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1()2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1()1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1()2 and HLA-DRB1()1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.
AU - Moffatt,MF
AU - Schou,C
AU - Faux,JA
AU - Cookson,WO
DO - 10.1007/s002510050266
EP - 230
PY - 1997///
SN - 0093-7711
SP - 226
TI - Germline TCR-A restriction of immunoglobulin E responses to allergen.
T2 - Immunogenetics
UR - http://dx.doi.org/10.1007/s002510050266
UR - https://www.ncbi.nlm.nih.gov/pubmed/9211749
VL - 46
ER -
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