In this section
@article{Bernard:2026:10.1016/j.biortech.2026.135437,
author = {Bernard, A and Ledesma-Amaro, R and Rossignol, T and Park, Y-K},
doi = {10.1016/j.biortech.2026.135437},
journal = {Bioresource Technology},
title = {Synthetic communities of Yarrowia lipolytica for efficient betanin bioproduction through metabolic partitioning},
url = {http://dx.doi.org/10.1016/j.biortech.2026.135437},
volume = {461},
year = {2026}
}
TY - JOUR
AB - In bioproduction, synthetic microbial consortia have the potential to outcompete single-strain systems by distributing metabolic burden and partitioning tasks more effectively. Obligatory cross-feeding of essential metabolites, or syntrophy, is a promising strategy to stabilize consortium composition and prevent population drift. In this study, we screened 56 co-auxotrophic pairs capable of establishing syntrophy in the unconventional yeast Yarrowia lipolytica. Further characterization of these consortia revealed diverse growth dynamics and population distributions across various inoculation ratios. A selection of syntrophic consortia was evaluated for the production of the natural value-added pigment, betanin, as a proof-of-concept. By redistributing the metabolic load across different co-culture designs, we achieved higher betanin titers (136.2 mg/L) in syntrophic co-cultures compared to monoculture by 1.5-fold in microbioreactor conditions. This study provides a platform of Y. lipolytica syntrophic consortia to produce metabolically demanding compounds more efficiently.
AU - Bernard,A
AU - Ledesma-Amaro,R
AU - Rossignol,T
AU - Park,Y-K
DO - 10.1016/j.biortech.2026.135437
PY - 2026///
SN - 0960-8524
TI - Synthetic communities of Yarrowia lipolytica for efficient betanin bioproduction through metabolic partitioning
T2 - Bioresource Technology
UR - http://dx.doi.org/10.1016/j.biortech.2026.135437
VL - 461
ER -
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