In this section
@article{Cookson:2011:10.1513/pats.201101-003MS,
author = {Cookson, WOC and Moffatt, MF},
doi = {10.1513/pats.201101-003MS},
journal = {Proc Am Thorac Soc},
pages = {149--153},
title = {Genetics of complex airway disease.},
url = {http://dx.doi.org/10.1513/pats.201101-003MS},
volume = {8},
year = {2011}
}
TY - JOUR
AB - The past 3 years have seen highly significant genetic effects identified for a wide variety of common complex diseases, including the airway disorders of asthma and chronic obstructive pulmonary disease. It appears that only a portion of the genetically mediated susceptibility to complex diseases has been identified, and there is much left to be discovered. This review briefly describes the results of the genome-wide association studies of asthma and gives an overview of the parallel and increasingly large-scale studies that are taking place with chronic obstructive pulmonary disease. The future impact is discussed of technological advances that allow increasingly large-scale gene expression studies, next-generation sequencing, and genome-wide testing for epigenetic effects. The use of genetic technology to examine the airway microbiota that interact with the mucosa in health and disease is described.
AU - Cookson,WOC
AU - Moffatt,MF
DO - 10.1513/pats.201101-003MS
EP - 153
PY - 2011///
SP - 149
TI - Genetics of complex airway disease.
T2 - Proc Am Thorac Soc
UR - http://dx.doi.org/10.1513/pats.201101-003MS
UR - https://www.ncbi.nlm.nih.gov/pubmed/21543792
VL - 8
ER -
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