The publications below have arisen from the material supply or service provision from the Imperial College Healthcare Tissue Bank;




Contractor, K., Aboagye, E.O., Jacob, J., Challapalli, A., Coombes, R.C., & Stebbing, J. (2012) Monitoring early response to taxane therapy in advanced breast cancer with circulating tumor cells and [(18)F] 3´-deoxy-3´-fluorothymidine PET: a pilot study. Biomarkers in Medicine. 6(2):231-3.
PMID: 22448798. DOI: 10.2217/bmm.12.11.

 Payne, R.E., Hava, N.L., Page, K., Blighe, K., Ward, B., Slade, M., Brown, J., Guttery, D.S., Zaidi, S.A., Stebbing, J., Jacob, J., Yagüe, E., Shaw, J.A., & Coombes, R.C. (2012) The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy. British Journal of Cancer. 106(2):375-82.
PMID: 22166803. DOI: 10.1038/bjc.2011.537.


Caballero, O.L., Shousha, S., Zhao, Q., Simpson, A.J., Coombes, R.C., & Neville, A.M. (2013) Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast. Oncoscience. 1(1):14-20.
PMID: 25593980. 

Huang, J., Kumar, S., Abbassi-Ghadi, N., Spanel, P., Smith, D., & Hanna, G.B. (2013) Selected ion flow tube mass spectrometry analysis of volatile metabolites in urine headspace for the profiling of gastro-esophageal cancer. Analytical Chemistry. 19;85(6):3409-16.
PMID: 23421902. DOI: 10.1021/ac4000656.

Kumar, S., Huang, J., Abbassi-Ghadi, N., Spanel, P., Smith, D., Hanna, G.B. (2013) Selected ion flow tube mass spectrometry analysis of exhaled breath for volatile organic compound profiling of esophago-gastric cancer. Analytical Chemistry. 85(12):6121-8.
PMID: 23659180. DOI: 10.1021/ac4010309.


Abbassi-Ghadi, N., Veselkov, K., Kumar, S., Huang, J., Jones, E., Strittmatter, N., Kudo, H., Goldin, R., Takáts, Z., Hanna, G.B. (2014) Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging. Chemical Communications (Cambridge). 50(28):3661-4.
PMID: 24407514. DOI: 10.1039/c3cc48927b.

Blighe, K., Kenny, L., Patel, N., Guttery, D.S., Page, K., Gronau, J.H., Golshani, C., Stebbing, J., Coombes, R.C., & Shaw, J.A. (2014) Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes. PLoS One.  9(12):e115346.
PMID: 25546409 DOI: 10.1371/journal.pone.0115346.

Filipović, A., Lombardo, Y., Faronato, M., Abrahams, J., Aboagye, E., Nguyen, Q.D., d'Aqua, B.B., Ridley, A., Green, A., Rahka, E., Ellis, I., Recchi, C., Przulj, N., Sarajlić, A., Alattia, J.R., Fraering, P., Deonarain, M., & Coombes, R.C. (2014) Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer  cells. Breast Cancer Research and Treatment. 148(2):455-62.
PMID: 25248409. DOI: 

Lombardo, Y., Faronato, M., Filipovic, A., Vircillo, V., Magnani, L., & Coombes, R.C. (2014) Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells. Breast Cancer Research. 16(3):R62.
PMID: 24919951 DOI: 10.1186/bcr3675.

Myatt, S.S., Kongsema, M., Man, C.W., Kelly, D.J., Gomes, A.R., Khongkow, P., Karunarathna, U., Zona, S., Langer, J.K., Dunsby, C.W., Coombes, R.C., French, P.M., Brosens, J.J., & Lam, E.W. (2014) SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene. 33(34):4316-29.
PMID: 24362530 DOI: 10.1038/onc.2013.546.

Rudraraju, B., Droog, M., Abdel-Fatah, T.M., Zwart, W., Giannoudis, A., Malki, M.I., Moore, D., Patel, H., Shaw, J., Ellis, I.O., Chan, S., Brooke, G.N., Nevedomskaya, E., Lo Nigro, C., Carroll, J., Coombes, R.C., Bevan, C., Ali, S., & Palmieri, C. (2014) Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer. Breast Cancer Research and Treatment. 147(2):295-309.
PMID: 25141981. DOI: 10.1007/s10549-014-3098-0.

Stebbing, J., Harding, V., Urch, C.E., Kaier, T., Schofield, G., Flook, M., Alifrangis, C., Young, A.M., Shaw, J.A., Coombes, R.C., & Krell, J. (2014) The prognostic role of circulating tumor cells in heavily pretreated individuals with a low life expectancy. Future Oncology10(16):2555-60.
PMID: 24877667. DOI: 10.2217/FON.14.107

Strittmatter, N., Rebec, M., Jones, E.A., Golf, O., Abdolrasouli, A., Balog, J., Behrends, V., Veselkov, K.A., & Takats, Z. (2014) Characterization and identification of clinically relevant microorganisms using rapid evaporative ionization mass spectrometry. Analytical Chemistry. 86(13):6555-62.
PMID: 24896667. DOI: 10.1021/ac501075f.

Veselkov, K.A., Mirnezami, R., Strittmatter, N., Goldin, R.D., Kinross, J., Speller, A.V., Abramov, T., Jones, E.A., Darzi, A., Holmes, E., Nicholson, J.K., & Takats, Z. (2014) Chemo-informatic  strategy for imaging mass spectrometry-based hyperspectral profiling of lipid signatures in colorectal cancer. Proceedings of the National Academy of Sciences of the United States of America. 111(3):1216-21.
PMID: 24398526 DOI: 10.1073/pnas.1310524111. 

Mirnezami, R., Spagou, K., Vorkas, P.A., Lewis, M.R., Kinross, J., Want, E., Shion, H., Goldin, R.D., Darzi, A., Takats, Z., Holmes, E., Cloarec, O., & Nicholson, J.K. (2014)  Chemical mapping of the colorectal cancer microenvironment via MALDI imaging mass spectrometry (MALDI-MSI) reveals novel cancer-associated field effects. Molecular Oncology. 8(1):39-49.
PMID: 24112879 DOI: 10.1016/j.molonc.2013.08.010.


Adams, C., Cazzanelli, G., Rasul, S., Hitchinson, B., Hu, Y., Coombes, R.C., Raguz, S., & Yagüe, E. (2015) Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance. Oncology Reports. 34(1):415-22.
PMID: 25998939. DOI: 10.3892/or.2015.3988.

Challapalli, A., Trousil, S., Hazell, S., Kozlowski, K., Gudi, M., Aboagye, E.O., &  Mangar, S. (2015) Exploiting altered patterns of choline kinase-alpha expression on human prostate tissue to prognosticate prostate cancer. Journal of Clinical Pathology. 68(9):703–709.
PMID: 26041862. DOI:10.1136/jclinpath-2015-202859.

Balog, J., Kumar, S., Alexander, J., Golf, O., Huang, J., Wiggins, T., Abbassi-Ghadi, N., Enyedi, A., Kacska, S., Kinross, J., Hanna, G.B., Nicholson, J.K., & Takats, Z. (2015) In vivo endoscopic tissue identification by rapid evaporative ionization mass spectrometry (REIMS). Angewandte Chemie (International Ed in English). 54(38):11059-62.
PMID: 26248566. DOI: 

Chiappini, C., Campagnolo, P., Almeida, C.S., Abbassi-Ghadi, N., Chow, L.W., Hanna, G.B., Stevens, M.M. (2015) Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles. Adv Mater. 27(35):5147-52.
PMID: 26197973. DOI: 10.1002/adma.201501304.

Golf, O., Muirhead, L.J., Speller, A., Balog, J., Abbassi-Ghadi, N., Kumar, S., Mróz, A., Veselkov, K., & Takáts, Z. (2015) XMS: cross-platform normalization method for multimodal mass spectrometric tissue profiling. Journal of the American Society for Mass Spectrometry. 26(1):44-54.
PMID: 25380777. DOI: 10.1007/s13361-014-0997-6.

Faronato, M., Nguyen, V.T., Patten, D.K., Lombardo, Y., Steel, J.H., Patel, N., Woodley, L., Shousha, S., Pruneri, G., Coombes, R.C., & Magnani, L. (2015) DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation. Oncotarget. 6(26):22467-79.
PMID: 26093085. DOI: 10.18632/oncotarget.4164.

Guenther, S., Muirhead, L.J., Speller, A.V., Golf, O., Strittmatter, N., Ramakrishnan, R., Goldin, R.D., Jones, E., Veselkov, K., Nicholson, J., Darzi, A., & Takats, Z. (2015) Spatially resolved metabolic phenotyping of breast cancer by desorption electrospray ionization mass spectrometry. Cancer Research. 75(9):1828-37.
PMID: 25691458. DOI:

Guttery, D.S., Page, K., Hills, A., Woodley, L., Marchese, S.D., Rghebi, B., Hastings, R.K., Luo, J., Pringle, J.H., Stebbing, J., Coombes, R.C., Ali, S., & Shaw, J.A. (2015) Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer. Clinical Chemistry. 61(7):97482. 
PMID: 25979954. DOI:10.1373/clinchem.2015.238717.

Larner, F., Shousha, S., & Coombes, R.C. (2015) Zinc isotopes: a novel approach to biomarkers of breast cancer? Biomarkers in Medicine. 9(4):379-82.
PMID: 25808441. DOI10.2217/bmm.15.8. 

Larner, F., Woodley, L.N., Shousha, S., Moyes, A., Humphreys-Williams, E., Strekopytov, S., Halliday, A.N., Rehkämper, M., & Coombes, R.C. (2015) Zinc isotopic compositions of breast cancer tissue. Metallomics. 7(1):112-7.
PMID: 25489714. DOI: 10.1039/c4mt00260a.

Lin, M.L., Patel, H., Remenyi, J., Banerji, C.R., Lai, C.F., Periyasamy, M., Lombardo, Y., Busonero, C., Ottaviani, S., Passey, A., Quinlan, P.R., Purdie, C.A., Jordan, L.B., Thompson, A.M., Finn, R.S., Rueda, O.M., Caldas, C., Gil, J., Coombes, R.C., Fuller-Pace, F.V., Teschendorff, A.E., Buluwela, L., & Ali, S. (2015) Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer. Oncotarget. 6:21685-703.
PMID: 26280373. DOI: 10.18632/oncotarget.3942.

Magnani, L., Patten, D.K., Nguyen, V.T., Hong, S.P., Steel, J.H., Patel, N., Lombardo, Y., Faronato, M., Gomes, A.R., Woodley, L., Page, K., Guttery, D., Primrose, L., Fernandez Garcia, D., Shaw, J., Viola, P., Green, A., Nolan, C., Ellis, I.O., Rakha, E.A., Shousha, S., Lam, E.W., Győrffy, B., Lupien, M., & Coombes, R.C. (2015) The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer. Oncotarget. 6(26):21878-91.
PMID: 26215677. DOI: 10.18632/oncotarget.4243.

Nguyen, V.T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J.H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D.K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R.C., & Magnani, L. (2015) Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature Communications. 6:10044.
PMID:26610607. DOI: 

Periyasamy, M., Patel, H., Lai, C.F., Nguyen, V.T., Nevedomskaya, E., Harrod, A., Russell, R., Remenyi, J., Ochocka, A.M., Thomas, R.S., Fuller-Pace, F., Győrffy, B., Caldas, C., Navaratnam, N., Carroll, J.S., Zwart, W., Coombes, R.C., Magnani, L., Buluwela, L., & Ali, S. (2015)  APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer. Cell Reports. 13(1):108-21.
PMID: 26411678. DOI:10.1016/j.celrep.2015.08.066.

Saleem, A., Searle, G.E., Kenny, L.M., Huiban, M., Kozlowski, K., Waldman, A.D., Woodley, L.,  Palmieri, C., Lowdell, C., Kaneko, T., Murphy, P.S., Lau, M.R., Aboagye, E.O., & Coombes, R.C. (2015) Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer. EJNMMI Research. 5:30.
PMID: 25977884. DOI: 

Sovova, K., Wiggins, T., Markar, S.R., & Hanna, G.B. (2015) Quantification of phenol in urine headspace using SIFT-MS and investigation of variability with respect to urinary concentration. Analytical Methods. 12(7)5134-5141.
DOI: 10.1039/C5AY01051A.


Abbassi-Ghadi, N., Jones, E.A., Gomez-Romero, M., Golf, O., Kumar, S., Huang, J., Kudo, H., Goldin, R.D., Hanna, G.B., & Takats, Z. (2016) A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue. Journal of the American Society for Mass Spectrometry. 27 (2): 255-64.
PMID: 26466600. DOI: 10.1007/s13361-015-1278-8.

Abbassi-Ghadi, N., Golf, O., Kumar, S., Antonowicz, S., McKenzie, J.S., Huang, J., Strittmatter, N., Kudo, H., Jones, E.A., Veselkov, K., Goldin, R., Takáts, Z., Hanna, G.B. (2016) Imaging of esophageal lymph node metastases by desorption electrospray ionization mass spectrometry Cancer Research. 76 (19): 5647-5656.
PMID: 27364550. DOI: 10.1158/0008-5472.CAN-16-0699.

Amrania, H., Drummond, L., Coombes, R.C., Shousha, S., Woodley-Barker, L., Weir, K., Hart, W., Carter, I., & Phillips, C.C. (2016) New IR imaging modalities for cancer detection and for intra-cell chemical mapping with a sub-diffraction mid-IR s-SNOM. Faraday Discussions.  187: 539-53.
PMID: 27077445. DOI: 10.1039/c5fd00150a.

Anderson, O., Carr, R., Harbinson, M., & Hanna, G.B. (2016) Development and validation of a lipase nasogastric tube position test. BMJ Open Gastroenterology.  2;3(1):e000064.
PMID: 26966548. DOI: 10.1136/bmjgast-2015-000064.

Krusche, B., Ottone, C., Clements, M.P., Johnstone, E.R., Goetsch, K., Lieven, H., Mota S.G., Singh, P., Khadayate, S., Ashraf, A., Davies, T., Pollard, S.M., De Paola, V., Roncaroli, F., Martinez-Torrecuadrada, J., Bertone, P., & Pattinello, S. (2016) EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells. eLife. 5: e14845.
PMID: 27350048. DOI: 10.7554/eLife.14845.

Tillner, J., McKenzie, J.S., Jones, E.A., Speller, A.V., Walsh, J.L., Veselkov, K.A., Bunch, J., Takats, Z., & Gilmore, I.S. (2016) Investigation of the Impact of Desorption ElectrosprayIonization Sprayer Geometry on Its Performance in Imaging of Biological Tissue. Analytical Chemistry. 88(9): 4808-16.
PMID: 27014929. DOI: 10.1021/acs.analchem.6b00345.

Zwart, W., Flach, K.D., Rudraraju, B., Abdel-Fatah, T.M., Gojis, O., Canisius, S., Moore, D., Nevedomskaya, E., Opdam, M., Droog, M., Hofland, I., Chan, S., Shaw, J., Ellis, I.O., Coombes, R.C., Carroll, J.S., Ali, S., & Palmieri, C. (2016) SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer. Clinical Cancer Research. 22:479-91.
PMID: 26369632. DOI: 10.1158/1078-0432.CCR-14-3277.

Ma S, Boughton O, Karunaratne A, Jin A, Cobb JP, Hansen U, Abel RL. (2016). Synchrotron imaging assessment of bone quality. Clinical Reviews in Bone & Mineral Metabolism 14:150.


 Afshar, B., Turner, C.E., Lamagni, T.L., Smith, K.C., Al-Shabib, A., Underwood, A., Holden, M.T.G., Efstratious, A., Sriskandan, S. (2017) Enhanced nasopharyngeal infection and shedding associated with an epidemic lineage of emm3 group A Sreptocuccus. Virulence. 8(7):1390-1400
PMID: 28457962. DOI:10.1080/21505594.2017.1325070. 

Afzali, B., Grönholm, J., Vandrovcova, J., O'Brien, C., Sun, H., Vanderleyden, I., Davis, F.P., Khoder, A., Zhang, Y., Hegazy, A.N., Villarino, A.V., Palmer, I.W., Kaufman, J., Watts, N.R., Kazemian, M., Kamenyeva, O., Keith, J., Sayed, A., Kasperaviciute, D., Mueller, M., Hughes, J.D., Fuss, I.L., Montgomery-Recht, K., McElwee, J., Restifo, N.P., Strober, W., Linterman, M.A., Wingfield, P.T., Uhlig, H.H., Rovchoudhuri, R., Aitman, T.J., Kelleher, P., Lenardo, M.J., O'Shea, J.J., Cooper, N., & Laurence, A.D.J. (2017) BACH2-immunodeficiency illustrates an association between super-enhancers and haplo-insufficiency. Nature Immunology. 18(7):813-823.
PMID: 28530713. DOI: 10.1038/ni.3753.

Cooke, S.L., Ennis, D., Evers, L., Dowson, S., Chan, M.Y., Paul, J., Hirschowitz, L., Glasspool, R.M., Singh, N., Bell, S., Day, E., Kochman, A., Wilkinson, N., Beer, P., Martin, S., Millan, D., Biankin, A.V., & McNeish, I.A. – on behalf of the Scottish Genomes Partnership (2017) The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma. Clinical Cancer Research. 23 (24): 7633 – 7640.
PMID: 28954785, DOI: 10.1158/1078-0432.CCR-17-1789. 

Feildon, T. (2017) Osteoporosis drugs may make bones weaker. BBC News Online, 1 March 2017. 

Goranova, T., Ennis, D., Piskorz, A.M., Macintyre, G., Lewsley, L.A., Stobo, J., Wilson, C., Kay, D., Glasspool, R.M., Lockley, M., Brockbank, E., Montes, A., Walther, A., Sunday, S., Edmondson, R., Hall, G.D., Clamp, A., Gourley, C., Hall, M., Fotopoulou, C., Gabra, H., Freeman, S., Moore, L., Jimenez-Linan, M., Paul, J., Brenton, J.D., & McNeish, I.A. (2017) Safety and utility of image-guided research biopsies in relapsed high-grade serious ovarian carcinoma-experience of the BriTROC consortium. British Journal of Cancer. 116 (10): 1294 – 1301.
PMID: 28359078. DOI: 10.1038/bjc.2017.86. 

Jin, A., Cobb, J., Hansen, U., Bhattacharya, R., Reinhard, C., Vo, N., Atwood, R., Li, J., Karunaratne, A., Wiles, C., & Abel, R. (2017) The effect of long-term bisphosphonate therapy on trabecular cone strength and microcrack density. Bone and Joint Research. 6 (10): 602 – 609.
PMID: 29066534, DOI: 10.1302/2046-3758.610.BJR-2016-0321.R1. 

Khara, J.S., Obuobi, S., Wang, Y., Hamilton, M.S., Robertson, B.D., Newton, S.M., Yang, Y.Y., Langford, P.R., Ee, P.L.R. (2017) Disruption of drug-resistant biofilms using de novo designed short α-helical antimicrobial peptides with idealized facial amphiphilicity. Acta Biomaterialia. 57; 103 – 114.
PMID: 28457962. DOI: 10.106/j.actbio.2017.04.032. 

Ma, S., Goh, E.L., Jin, A., Bhattacharya, R., Boughton, O.R., Patel, B., Karunaratne, A., Vo, N.T., Atwood, R., Cobb, J.P., Hansen, U., & Abel, R.L. (2017) Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties. Scientific Reports. 7:43399.
PMID: 28262693. DOI: 10.1038/srep43399. 

Sim, M.J., Malaker, S.A., Khan, A., Stowell, J.M., Shabanowitz, J., Peterson, M.E., Rajagopalan, S., Hunt, D.F., Altmann, D.M., Long, E.O., & Boyton, R.J. (2017) Canonical and Cross-reactive Binding of NK Cell Inhibitory Receptors to HLA-A Allotypes is Dictated by Peptides Bound to HLA-C. Frontiers in Immunology. 14 (8): 103. 
PMID: 28352266. DOI: 10.3389/fimmu.2017.00193.

Stratigou, V., Doyle, A.F., Carlucci, F., Stephens, L., Foschi, V., Castelli, M., McKenna, N., Cook, H.T., Lightstone, L., Cairns, T.D., Pickering, M.C., & Botto, M. (2017) Altered expression of signalling lymphocyte activation molecule receptors in T-cells from lupus nephritis patients – a potential biomarker of disease activity. Rheumatology (Oxford). 56 (7); 1206 – 1216.
PMID: 28387859. DOI: 10.1093/rheumatology/kex078. 

You, A.Y.F., Bergholt, M.S., St. Pierre, J.P., Kit-Anan, W., Pence, J., Chester, A.H., Yacoub, M.H., Bertazzo, S., & Stevens, M.M. (2017) Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in human aorta. Scientific Advances. 3 (12): e1701156.
PMID: 29226241. DOI: 10.1126/sciadv.1701156 

Page K, Guttery DS, Fernandez-Garcia D, Hills A, Hastings RK, Luo J, Goddard K, Shahin V, Woodley-Barker L, Rosales BM, Coombes RC, Stebbing J, Shaw JA. (2017) Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer. Clin Chem. 2017 Feb;63(2):532-541. DOI: 10.1373/clinchem.2016.261834. Epub 2016 Dec 9.PMID: 27940449

Shaw JA, Guttery DS, Hills A, Fernandez-Garcia D, Page K, Rosales BM, Goddard KS, Hastings RK, Luo J, Ogle O, Woodley L, Ali S, Stebbing J, Coombes RC. (2019) Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts. Clin Cancer Res. 2017 Jan 1;23(1):88-96. DOI: 10.1158/1078-0432.CCR-16-0825. Epub 2016 Jun 22.PMID: 27334837





Boughton, O.R, Ma, S., Zhao, S., Arnold, M., Lewis, A., Hansen, U., Cobb, J.P., Giuliani, F., & Abel R.L. (2018) Measuring bone stiffness using spherical indentation. PLoS One. 13 (7): e0200475.
PMID: 30001364. DOI: 10.1371/journal.pone.0200475.

Curry, E., Zeller, C., Masrour, N., Patten, D.K., Gallon, J., Wilhelm-Benartzi, C.S., Ghaem-Maghami, S., Bowtell, D.D., & Brown, R. (2018) Genes Predisposed to DNA Hypermethylation during Acquired Resistance to Chemotherapy are Identified in Ovarian Tumours by Bivalent Chromatin Domains at Initial Diagnosis. Cancer Research. 78 (6): 1383 – 1391.
PMID: 29339543. DOI: 10.1158/0008-5472.CAN-17-1650. 

Ghetti, M., Topouzi, H., Theocharidis, G., Papa, V., Williams, G., Bondioli, E., Cennacchi, G., Connelly, J.T., & Higgins, C.A. (2018) Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic. British Journal of Dermatology.
PMID: 29266210. DOI:10.1111/bjd.16255. 

Markoska, A., Mendoza, L.C., Valaiyapathi, R., Thorn, C., & Dornhorst, A. (2018) Insulin sensitivity assessed using urine C-peptide creatinine ratio (UCPCR) in pregnancy: a cross sectional analysis of an English multi-ethnic cohort. BMJ Open. 8 (5): e020029. 
PMID: 29724737. DOI: 10.1136/bmjopen-2017-020029. 

Mason, S., Alexander, J.L., White, E., Bodai, Z., Manoli, E., Paizs, P., Alasdair, S., Adebesin, A., Hoare, J., Goldin, R., Darzi, A., Takats, Z., & Kinross, J.M. (2018) Sa1207 – Prospective Observational Cohort Study of Rapid Ionization Mass Spectrometry (REIMS) for Near-Real Time Diagnosis and Stratification of Colorectal Cancer. Gastroenterology. 154 (6) 1 S277- S278. 

Phelps, D.L., Balog, J., Gildea, L.F., Bodai, Z., Savage, A., El-Bahrawy, M.A., Speller, A.V., Rosini, F., Kudo, H., McKensie, J.S., Brown, R., Takats, Z., & Ghaem-Maghami, S. (2018) The surgical intelligent knife distinguishes normal, borderline and malignany gynaecological tissues using rapid evaporative ionisation mass spectrometry (REIMS).  British Journal of Cancer. 118 (10): 1349 – 1358.
PMID: 29670294. DOI: 10.1038/s41416-018-0048-3. 

Pickles, J.C., Hawkins, C., Pietsch, T., & Jacques, T.S. (2018) CNS embryonal tumours: WHO 2016 and beyond. Neuropathology and Applied Neurobiology. 44 (2): 151 – 162.
PMID: 28949028. DOI: 10.1111/nan.12443. 

Pinato, D.J., Mauri, F.A., Spina, P., Cain, O., Siddique, A., Goldin, R.D., Victor, S., Pizio, C., Akarca, A., Boldorini, R., Mazzucchelli, L., Black, J.M., Shetty, S., Marafioti, T., & Sharma, R. (2018) Quantitative compatison of PD-L1 immuno-histochemical assays in hepatocellular carcinoma: The Blueprint-HCC study. Journal of Clinical Oncology. 36 (5) 91. 
DOI: 10.1016/S0168-8278(18)31595-2 

Stronach, E.A., Paul, J., Timms, K.M., Hughes, E., Brown, E., Brown, K., Neff, C., Perry, M., Gutin, A., El-Bahrawy, M., Steel, J.H., Liu, X., Lewsley, L.A., Siddiqui, N., Gabra, H., Lanchbury, J.S., & Brown, R. (2018) Biomarker Assessment of HR Deficiency, Tumour BRCA ½ Mutations, and CCNE1 Copy Number in Ovarian Cancer: Association with Clinical Outcome Following Platinum Monotherapy. Molecular Cancer Research. 16(7): 1103-1111.
PMID: 29724815. DOI: 10.1158/1541-7786.MCR-18-0034. 

Taheem, D.K., Foyt, D.A., Loaiza, S., Ferreira, S.A., Ilic, D., Auner, H.W., Grigoriadis, A.E., Jell, G., & Gentleman, E. (2018) Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors.  Stem Cells Journals. 
PMID: 29726060. DOI: 10.1002/stem.2844 

Teraz-Orosz, A., Cooper, N., Crawley, J.T.B., Salles-Crawley, I.I. (2018) Detection of anti-platelet antibodies in immune thrombocytopenia by flow cytometry. British Journal of Haematology.
PMID: 29532906. DOI: 10.1111/bjh.15187. 

M C U Cheang 1, J M Bliss 1, G Viale 2, V Speirs 3, C Palmieri 4, A Shaaban 5, P E Lønning 6, J Morden 1, N Porta 1, J Jassem 7, C J van De Velde 8, B B Rasmussen 9, D Verhoeven 10, J M S Bartlett 11, R C Coombes 12, PathIES Sub-Committee (2018) Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES Breast Cancer Res Treat. 168(1):169-178.
PMID: 29177605 PMCID: PMC5847042 DOI: 10.1007/s10549-017-4543-7


Lynskey NN, Jauneikaite E, Li HK, Zhi X, Turner CE, Mosavie M, Pearson M, Asai M, Lobkowicz L, Chow JY, Parkhill J, Lamagni T, Chalker VJ, Sriskandan S. (2019)  Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study. Lancet Infect Dis. 2019 Nov;19(11):1209-1218. DOI: 10.1016/S1473-3099(19)30446-3. Epub Sep 10.PMID: 31519541

Sharma H, Turner CE, Siggins MK, El-Bahrawy M, Pichon B, Kearns A, Sriskandan S.mSphere (2019) Toxic Shock Syndrome Toxin 1 Evaluation and Antibiotic Impact in a Transgenic Model of Staphylococcal Soft Tissue Infection. Oct 9;4(5):e00665-19. DOI: 10.1128/mSphere.00665-19.PMID: 31597722

 Watson, S.A., Duff, J., Bardi, I., Zabielska, M., et al. (2019) Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro. Nature Communications. [Online]. 10 (1). Available from: doi: 10.1038/s41467-019-10175-3. 

Boughton O, Ma, S, Cai X, Yan L, Pereira LMP, Laugier P, Marrow J, Finn G, Hansen UN, Grimal Q, Cobb J, Abel RL. (2019). Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties. Scientific Reports 7416:1-15.

Fernandez-Garcia D, Hills A, Page K, Hastings RK, Toghill B, Goddard KS, Ion C, Ogle O, Boydell AR, Gleason K, Rutherford M, Lim A, Guttery DS, Coombes RC, Shaw JA. (2019) Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer. Breast Cancer Res. 2019 Dec 19;21(1):149. DOI: 10.1186/s13058-019-1235-8.PMID: 31856868

Coombes RC, Page K, Salari R, Hastings RK, Armstrong A, Ahmed S, Ali S, Cleator S, Kenny L, Stebbing J, Rutherford M, Sethi H, Boydell A, Swenerton R, Fernandez-Garcia D, Gleason KLT, Goddard K, Guttery DS, Assaf ZJ, Wu HT, Natarajan P, Moore DA, Primrose L, Dashner S, Tin AS, Balcioglu M, Srinivasan R, Shchegrova SV, Olson A, Hafez D, Billings P, Aleshin A, Rehman F, Toghill BJ, Hills A, Louie MC, Lin CJ, Zimmermann BG, Shaw JA.(2019) Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence. Clin Cancer Res. 2019 Jul 15;25(14):4255-4263. DOI: 10.1158/1078-0432.CCR-18-3663. Epub 2019 Apr 16.PMID: 30992300

Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D, Jones PS, Jones R, Marshall JF, Panico MB, Shaw JA, Steeg PS, Sullivan M, Tong W, Westwell AD, Ritchie JWA; (2019) A framework for the development of effective anti-metastatic agents. Cancer Research UK and Cancer Therapeutics CRC Australia Metastasis Working Group.Nat Rev Clin Oncol. 2019 Mar;16(3):185-204. DOI: 10.1038/s41571-018-0134-8.PMID: 30514977

Koch, M., Cegla, J., Jones, B., Lu, Y., Mallat, Z., Blagborough, A. M., Angrisano, F., & Baum, J. (2019). The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection. Malaria Journal18(1), 381. PMID: 31783858

Malczewska A, Frampton AE, Mato Prado M, Ameri S, Dabrowska AF, Zagorac S, Clift AK, Kos-Kudła B, Faiz O, Stebbing J, Castellano L, Frilling A. (2019) Circulating MicroRNAs in Small-bowel Neuroendocrine Tumors: A Potential Tool for Diagnosis and Assessment of Effectiveness of Surgical Resection. Ann Surg. DOI: 10.1097/SLA.0000000000003502. Epub ahead of print. PMID: 31373926.


Liye Yan, Ahmet Cinar, Shaocheng Ma, Richard Abel, Ulrich Hansen, Thomas James Marrow. (2020) A method for fracture toughness measurement in trabecular bone using computed tomography, image correlation and finite element methods. JMBBM 109:103838.

Ma S, Goh EL, Tay T, Wiles C, Boughton O, Churchwell J, Karunaratne A, Bhattacharya R, Terrill N, Cobb JP, Hansen U, Abel RL. (2020). Role of mineral disengagement and fibril sliding in age-related hip-fractures. Scientific Reports. In Press.

Ajdari N, Tempelaere C, Imani MM, Abel R, Delfosse D, Emery R, Dini D, Hansen U. (2020). Hemiarthroplasties: the choice of prosthetic material causes different levels of damage in the articular cartilage. Journal of Shoulder and Elbow Surgery 29:2019-1029.

Kalofonou M, Malpartida-Cardenas K, Alexandrou G, Rodriguez-Manzano J, Yu LS, Miscourides N, Allsopp R, Gleason KLT, Goddard K, Fernandez-Garcia D, Page K, Georgiou P, Ali S, Coombes RC, Shaw J, Toumazou (2020) A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p.H1047R breast cancer mutation. C.Sci Rep. 2020 Mar 12;10(1):4553. doi: 10.1038/s41598-020-60852-3.PMID: 32165708

Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O'Connell JR, Mitchell BD; De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. (2020) National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Population Genetics Working Group, O'Connor TD.Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2560-2569. doi: 10.1073/pnas.1902766117. Epub 2020 Jan 21.PMID: 31964835

Leung EYL, Ennis D, Kennedy P, Hansell C, Dowson S, Farquharson M, Spiliopoulou P, Nautiyal J, McNamara S, Carlin LM, Fisher K, Davis DM, Graham G, McNeish IA; NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer (2020) Mol. Therapy Oncolytics, VOL 16, P289-301, DOI:

Avirup Chowdhury Sandra Loaiza Eva Yebra‐Fernandez Elisabet Nadal‐Melsio Jane F. Apperley Jamshid S. Khorashad (2020) An ex vivo investigation of interactions between primary acute myeloid leukaemia and mesenchymal stromal cells yields novel therapeutic targets., British Journal of Haematology


Peacock, T.P., Goldhill, D.H., Zhou, J. et al. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets. Nat Microbiol 6, 899–909 (2021).

Cai, S., Pataillot-Meakin, T., Shibakawa, A. et al. Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum. Nat Commun 12, 3515 (2021).

R. S. Thwaiteset al., Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19, (2021) Science Immunology 10.1126/sciimmunol.abg9873.

Herrera C, Harman S, Aldon Y, Rogers P, Armanasco N, Ziprin P, Stieh D, Nuttall J, Shattock RJ. The entry inhibitor DS003 (BMS-599793): a BMS-806 analogue, provides superior activity as a pre-exposure prophylaxis candidate. AIDS. 2021 Oct 1;35(12):1907-1917. doi: 10.1097/QAD.0000000000002974. PMID: 34101626; PMCID: PMC8416713.

Tan, L.K.K., Reglinski, M., Teo, D. et al. Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease. npj Vaccines 6, 62 (2021).

Thwaites R.S, Sanchez Sevilla Uruchurtu A., et al., Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19., Science Immunology 6, 57 (2021) DOI: 10.1126/sciimmunol.abg9873

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