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Publications

Modulation without surgical intervention

N. Grossman "Modulation without surgical intervention." Science 361.6401 (2018): 461-462.

Noninvasive deep brain stimulation

N. Grossman, D. Bono, S. Kodandaramaiah, A. Rudenko, A. Cassara, E. Neufeld, S. A. Anteraper, A. Takahashi, N. Kuster, L. Tsai, A. Pascual-Leone, E. S. Boyden “Noninvasive deep brain stimulation via delivery of temporally interfering electric fields.” Cell 169.6 (2017): 1029-1041.

Neuron Cell with Channelrhodopsin-2 Mutants light study

N. Grossman, K. Nikolic, C. Toumazou, P. Degenaar “Modeling Study of the Light Stimulation of a Neuron Cell with Channelrhodopsin-2 Mutants.” IEEE Trans Biomed

Multi-site optical excitation using ChR2 and micro-LED array

N. Grossman, V. Pohrer, M. Grubb, G. T. Kennedy, K. Nikolic, M. A. A. Neil, M. D. Dawson, J. Burrone, P. Degenaar “Multi-site optical excitation using ChR2 and micro-LED array.” J. Neural Eng. 7 (2010): 16004.

Citation

BibTex format

@article{Agnorelli:2026:10.1177/0271678X261431447,
author = {Agnorelli, C and Peill, J and Sawicka, G and Kurtin, D and Shatalina, E and Ahmad, K and Wall, MB and Rua, C and Godfrey, K and Ertl, N and Searle, G and Zhou, K and Osugo, M and Weiss, B and Greenway, KT and Fagiolini, A and Carhart-Harris, R and Matthews, PM and Rabiner, EA and Nutt, D and Erritzoe, D},
doi = {10.1177/0271678X261431447},
journal = {J Cereb Blood Flow Metab},
title = {Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.},
url = {http://dx.doi.org/10.1177/0271678X261431447},
year = {2026}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We investigated ketamine's neuroplastic effects in healthy human subjects using integrated Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) measures before and 1-8 days after a single psychedelic dose of ketamine (1 mg/kg, intravenous). Eleven male participants underwent two PET/MRI scans with [11C]-UCBJ (synaptic density/plasticity), 1H-MRS (glutamate and GABA) and resting-state fMRI (intrinsic brain activity, functional connectivity), before and after ketamine. While group-level analyses showed no significant increases in PET synaptic markers, ketamine administration resulted in significantly elevated glutamate levels within the anterior cingulate cortex (ACC). Functional connectivity analyses revealed reduced coupling between the ACC and the dorsolateral prefrontal cortex (dlPFC) and increased coupling between the ACC and the amygdala in the days following ketamine administration. Our multimodal analysis revealed that participants showing an increase in [11C]-UCBJ volume distribution (VT), a putative index of synaptic plasticity, showed a correlated reduction in intrinsic activity within regions belonging to the default mode network (DMN). By linking molecular, cellular and network-level changes, our results point to the DMN as a central hub where ketamine may reshape brain hierarchies in the long term, providing new directions for understanding its therapeutic mechanisms and developing targeted treatments.
AU  - Agnorelli,C
AU  - Peill,J
AU  - Sawicka,G
AU  - Kurtin,D
AU  - Shatalina,E
AU  - Ahmad,K
AU  - Wall,MB
AU  - Rua,C
AU  - Godfrey,K
AU  - Ertl,N
AU  - Searle,G
AU  - Zhou,K
AU  - Osugo,M
AU  - Weiss,B
AU  - Greenway,KT
AU  - Fagiolini,A
AU  - Carhart-Harris,R
AU  - Matthews,PM
AU  - Rabiner,EA
AU  - Nutt,D
AU  - Erritzoe,D
DO  - 10.1177/0271678X261431447
PY  - 2026///
TI  - Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.
T2  - J Cereb Blood Flow Metab
UR  - http://dx.doi.org/10.1177/0271678X261431447
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41863255
ER  -