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Publications

Modulation without surgical intervention

N. Grossman "Modulation without surgical intervention." Science 361.6401 (2018): 461-462.

Noninvasive deep brain stimulation

N. Grossman, D. Bono, S. Kodandaramaiah, A. Rudenko, A. Cassara, E. Neufeld, S. A. Anteraper, A. Takahashi, N. Kuster, L. Tsai, A. Pascual-Leone, E. S. Boyden “Noninvasive deep brain stimulation via delivery of temporally interfering electric fields.” Cell 169.6 (2017): 1029-1041.

Neuron Cell with Channelrhodopsin-2 Mutants light study

N. Grossman, K. Nikolic, C. Toumazou, P. Degenaar “Modeling Study of the Light Stimulation of a Neuron Cell with Channelrhodopsin-2 Mutants.” IEEE Trans Biomed

Multi-site optical excitation using ChR2 and micro-LED array

N. Grossman, V. Pohrer, M. Grubb, G. T. Kennedy, K. Nikolic, M. A. A. Neil, M. D. Dawson, J. Burrone, P. Degenaar “Multi-site optical excitation using ChR2 and micro-LED array.” J. Neural Eng. 7 (2010): 16004.

Citation

BibTex format

@article{Rintoul:2026:10.1038/s41467-026-73826-2,
author = {Rintoul, J and Butler, C and Cleveland, R and Grossman, N},
doi = {10.1038/s41467-026-73826-2},
journal = {Nature Communications},
title = {Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation},
url = {http://dx.doi.org/10.1038/s41467-026-73826-2},
volume = {17},
year = {2026}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Non-invasive brain stimulation offers therapeutic potential without surgery, yet existing electrical approaches lack spatial precision due to the long wavelengths of electric fields. Here we demonstrate acoustoelectric neuromodulation, a nonlinear interaction between applied acoustic and electric fields that generates spatially localised, low-frequency electric fields at the ultrasound focus. Using in vitro and in vivo mouse electrophysiology, we show motor-evoked responses that depend on both the amplitude and frequency of the acoustoelectric field, with controls excluding purely acoustic or electrical origins. In vivo measurements show acoustoelectric potentials of ≈9 mV, corresponding to estimated focal electric fields of ~6 V/m at 500 kHz and 1 MPa acoustic pressure, with ~1.5 mm extrema spacing demonstrated in phantom experiments. Importantly, we identify an acoustoelectric contribution to conventional ultrasound stimulation, arising from interactions between ultrasound-induced electrical signals and propagating acoustic waves, establishing acoustoelectric neuromodulation as a distinct mechanism influencing ultrasound-based brain stimulation.
AU  - Rintoul,J
AU  - Butler,C
AU  - Cleveland,R
AU  - Grossman,N
DO  - 10.1038/s41467-026-73826-2
PY  - 2026///
SN  - 2041-1723
TI  - Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-026-73826-2
VL  - 17
ER  -