In this section
@inbook{Seddon:2025:10.1201/9781003287650-3,
author = {Seddon, JM and Tyler, AII},
booktitle = {Membrane Shape and Biological Function},
doi = {10.1201/9781003287650-3},
pages = {42--60},
title = {Non-Lamellar Phases of Membrane Lipids},
url = {http://dx.doi.org/10.1201/9781003287650-3},
year = {2025}
}
TY - CHAP
AB - This chapter describes the self-assembly of membrane lipids into non-lamellar phases, whose structures are based upon curved fluid monolayers or bilayers. Such membrane curvature arises from a mismatch in the lateral packing between the lipid polar headgroups and the hydrocarbon chains. The relationship between lateral pressure profiles and membrane curvature elasticity is discussed, as well as the role of curvature and packing frustration in stabilizing curved membrane phases. Non-lamellar structures appear to play a role in a wide range of biological processes. For example, they are believed to be intimately involved in the mechanism of fat digestion in the gut. In any event, the localized dynamic shape changes that occur during biological processes such as membrane fusion and fission are geometrically and topologically closely related to the local structures of certain non-lamellar phases. Thus studies of the latter in model systems may yield valuable insights into the molecular rearrangements that occur during these complex dynamic biological processes. Non-lamellar phases also have a large number of existing or potential biomedical applications, such as in membrane protein crystallization, and drug/gene delivery to living cells. Self-assembled lipid nanoparticles with incorporated mRNA has led to the recent development of the highly-successful Covid-19 vaccine.
AU - Seddon,JM
AU - Tyler,AII
DO - 10.1201/9781003287650-3
EP - 60
PY - 2025///
SP - 42
TI - Non-Lamellar Phases of Membrane Lipids
T1 - Membrane Shape and Biological Function
UR - http://dx.doi.org/10.1201/9781003287650-3
ER -
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