In this section
@article{Ristic:2025:10.1002/mrm.30332,
author = {Ristic, M and Chappell, KE and Lanz, H and McGinley, JVM and Gupte, C and Amiras, D},
doi = {10.1002/mrm.30332},
journal = {Magnetic Resonance in Medicine},
pages = {1077--1089},
title = {First in-vivo magic angle directional imaging using dedicated low-field MRI},
url = {http://dx.doi.org/10.1002/mrm.30332},
volume = {93},
year = {2025}
}
TY - JOUR
AB - Purpose: To report the first in-vivo results from exploiting the magic angle effect, using a dedicated low-field MRI scanner that can be rotated about two axes. The Magic Angle Directional Imaging (MADI) method is used to depict collagen microstructures with 3D collagen tractography of knee ligaments and the meniscus. Methods: A novel low-field MRI system was developed, based on a transverse field open magnet, where the magnet can be rotated about two orthogonal. Sets of volume scans at various orientations were obtained in healthy volunteers. The experiments focused on the anterior cruciate ligament (ACL) and the meniscus of the knee. The images were co-registered, anatomical regions of interest (RoI) were selected and the collagen fiber orientations in each voxel were estimated from the observed image intensity variations. The 3D collagen tractography was superimposed on conventional volume images. Results: The MADI method was successfully employed for the first time producing in-vivo results comparable to those previously reported for excised animal specimens using conventional MRI. Tractography plots were generated for the ACL and the menisci. These results are consistent with the known microstructure of collagen fibers in these tissues. Conclusion: Images obtained using low-field MRI with 1 mm3 resolution were of sufficient quality for the MADI method, which was shown to produce high quality in-vivo information of collagen microstructures. This was achieved using a cost effective and sustainable low-field magnet making the technique potentially accessible and scalable, potentially changing the way we image injuries or disease in joints.
AU - Ristic,M
AU - Chappell,KE
AU - Lanz,H
AU - McGinley,JVM
AU - Gupte,C
AU - Amiras,D
DO - 10.1002/mrm.30332
EP - 1089
PY - 2025///
SN - 0740-3194
SP - 1077
TI - First in-vivo magic angle directional imaging using dedicated low-field MRI
T2 - Magnetic Resonance in Medicine
UR - http://dx.doi.org/10.1002/mrm.30332
UR - https://onlinelibrary.wiley.com/doi/10.1002/mrm.30332
VL - 93
ER -
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