Publications

BibTex format

@article{Statton:2026:10.1002/pul2.70426,
author = {Statton, B and Armour, C and Leong, K and Sedlacik, J and Berry, A and Jin, N and Giese, D and Guidice, FL and Howard, L and Gopalan, D},
doi = {10.1002/pul2.70426},
journal = {Pulm Circ},
title = {4D-Flow MRI-Derived Wall Shear Stress as a Non-Invasive Biomarker for the Detection and Hemodynamic Characterization of Pulmonary Hypertension.},
url = {http://dx.doi.org/10.1002/pul2.70426},
volume = {16},
year = {2026}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Invasive right heart catheterization (RHC) remains the reference standard for diagnosing pulmonary hypertension (PH), but there is a pressing need for non-invasive techniques to assess pulmonary hemodynamics. This study evaluates 4D-flow MRI-derived wall shear stress (WSS) for PH detection using the updated 2022 hemodynamic criteria, and the prediction of right ventriculo-pulmonary arterial (RV-PA) uncoupling to assess disease severity. 3D WSS was measured in the main (MPA), right (RPA), and left (LPA) pulmonary arteries in a retrospective validation cohort (41 PH patients, 23 non-PH) and then assessed in a prospective test cohort (23 PH patients, 17 healthy controls). For methodological validation, a patient-specific computational fluid dynamics (CFD) was performed in a subset of 16 patients from the validation cohort. RV-PA uncoupling was assessed on the cine MRI, using RV global longitudinal strain (GLS) < -15.3% and RVSV/RVESV < 1. Both 3D peak and time-averaged WSS were significantly reduced in PH patients compared with healthy controls. Global WSS metrics demonstrated the strongest correlations with invasive hemodynamic parameters, including mPAP (r = -0.75, p < 0.001) and PVR (r = -0.76, p < 0.001). ROC curve analysis identified a peak WSS cutoff of < 0.30 Pa (AUC 0.98) for PH detection, a threshold achieving 90% sensitivity and 100% specificity in the test cohort. Furthermore, a peak WSS threshold of < 0.18 Pa demonstrated excellent discriminative ability for RV-PA uncoupling. These findings support the potential integration of WSS analysis into routine CMR protocols as a non-invasive complement to RHC, showing promise for both diagnosis and a longitudinal biomarker for monitoring PH.
AU  - Statton,B
AU  - Armour,C
AU  - Leong,K
AU  - Sedlacik,J
AU  - Berry,A
AU  - Jin,N
AU  - Giese,D
AU  - Guidice,FL
AU  - Howard,L
AU  - Gopalan,D
DO  - 10.1002/pul2.70426
PY  - 2026///
SN  - 2045-8932
TI  - 4D-Flow MRI-Derived Wall Shear Stress as a Non-Invasive Biomarker for the Detection and Hemodynamic Characterization of Pulmonary Hypertension.
T2  - Pulm Circ
UR  - http://dx.doi.org/10.1002/pul2.70426
UR  - https://www.ncbi.nlm.nih.gov/pubmed/42898806
VL  - 16
ER  -

Download

Publications

Citation

BibTex format

RIS format (EndNote, RefMan)

Contact