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@article{Logan:2016:10.2337/dc16-0030,
author = {Logan, K and Emsley, RJ and Jeffries, S and Andrzejewska, I and Hyde, MJ and Gale, C and Chappell, K and Mandalia, S and Santhakumaran, S and Parkinson, JRC and Mills, L and Modi, N},
doi = {10.2337/dc16-0030},
journal = {Diabetes Care},
pages = {1045--1051},
title = {Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus},
url = {http://dx.doi.org/10.2337/dc16-0030},
volume = {39},
year = {2016}
}

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TY  - JOUR
AB  - OBJECTIVEInfants born to mothers with gestational diabetes mellitus (GDM) are at greaterrisk of later adverse metabolic health. We examined plausible candidate mediators;adipose tissue (AT) quantity and distribution, and intrahepatocellular lipid(IHCL) content, comparing infants of mothers with GDM and without GDM (controlgroup) over the first 3 postnatal months.RESEARCH DESIGN AND METHODSWe conducted a prospective longitudinal study using MRI and spectroscopy toquantify whole-body and regional AT volumes, and IHCL content, within 2 weeksand 8–12 weeks after birth. We adjusted for infant size and sex, and maternalprepregnancy BMI. Values are reported as the mean difference (95% CI).RESULTSWe recruited 86 infants (GDM group 42 infants; control group 44 infants). Motherswith GDM had good pregnancy glycemic control. Infants were predominantlybreast fed up to the time of the second assessment (GDM group 71%; controlgroup 74%). Total AT volumes were similar in the GDM group compared with thecontrol group at a median age of 11 days (228 cm3 [95% CI 2121, 65], P = 0.55), butwere greater in the GDM group at a median age of 10 weeks (247 cm3 [56, 439], P =0.01). After adjustment for size, the GDM group had significantly greater total ATvolume at 10 weeks than control group infants (16.0% [6.0, 27.1], P = 0.002). ATdistribution and IHCL content were not significantly different at either time point.CONCLUSIONSAdiposity in GDM infants is amplified in early infancy, despite good maternalglycemic control and predominant breast-feeding, suggesting a potential causalpathway to later adverse metabolic health. Reduction in postnatal adiposity maybe a therapeutic target to reduce later health risks.
AU  - Logan,K
AU  - Emsley,RJ
AU  - Jeffries,S
AU  - Andrzejewska,I
AU  - Hyde,MJ
AU  - Gale,C
AU  - Chappell,K
AU  - Mandalia,S
AU  - Santhakumaran,S
AU  - Parkinson,JRC
AU  - Mills,L
AU  - Modi,N
DO  - 10.2337/dc16-0030
EP  - 1051
PY  - 2016///
SN  - 0149-5992
SP  - 1045
TI  - Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus
T2  - Diabetes Care
UR  - http://dx.doi.org/10.2337/dc16-0030
VL  - 39
ER  -

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