In this section
@article{Montaldo:2016:10.1186/s12880-016-0137-9,
author = {Montaldo, P and Addison, S and Oliveira, V and Lally, PJ and Taylor, AM and Sebire, NJ and Thayyil, S and Arthurs, OJ},
doi = {10.1186/s12880-016-0137-9},
journal = {BMC MEDICAL IMAGING},
title = {Quantification of Maceration Changes using Post Mortem MRI in Fetuses},
url = {http://dx.doi.org/10.1186/s12880-016-0137-9},
volume = {16},
year = {2016}
}
TY - JOUR
AB - BackgroundPost mortem imaging is playing an increasingly important role in perinatal autopsy, andcorrect interpretation of imaging changes is paramount. This is particularly importantfollowing intra-uterine fetal death, where there may be fetal maceration. The aim of thisstudy was to investigate whether any changes seen on a whole body fetal post mortemmagnetic resonance imaging (PMMR) correspond to maceration at conventionalautopsy.Methods: We performed pre-autopsy PMMR in 75 fetuses using a 1.5 Tesla SiemensAvanto MR scanner (Erlangen, Germany). PMMR images were reported blinded to theclinical history and autopsy data using a numerical severity scale (0 = no macerationchanges to 2 = severe maceration changes) for 6 different visceral organs (total 12).The degree of maceration at autopsy was categorized according to severity on anumerical scale (1 = no maceration to 4 = severe maceration). We also generatedquantitative maps to measure the liver and lung T2.Results: The mean PMMR maceration score correlated well with the autopsymaceration score (R2=0.93). A PMMR score of ≥ 4.5 had a sensitivity of 91%,specificity of 64%, for detecting moderate or severe maceration at autopsy. Liver andlung T2 were increased in fetuses with maceration scores of 3-4 in comparison tothose with 1-2 (liver p=0.03, lung p=0.02).Conclusions: There was a good correlation between PMMR maceration score and theextent of maceration seen at conventional autopsy. This score may be useful ininterpretation of fetal PMMR.
AU - Montaldo,P
AU - Addison,S
AU - Oliveira,V
AU - Lally,PJ
AU - Taylor,AM
AU - Sebire,NJ
AU - Thayyil,S
AU - Arthurs,OJ
DO - 10.1186/s12880-016-0137-9
PY - 2016///
SN - 1471-2342
TI - Quantification of Maceration Changes using Post Mortem MRI in Fetuses
T2 - BMC MEDICAL IMAGING
UR - http://dx.doi.org/10.1186/s12880-016-0137-9
VL - 16
ER -
For enquiries about the MRI Physics Collective, please contact:
Mary Finnegan
Senior MR Physicist at the Imperial College Healthcare NHS Trust
Pete Lally
Assistant Professor in Magnetic Resonance (MR) Physics at Imperial College
Jan Sedlacik
MR Physicist at the Robert Steiner MR Unit, Hammersmith Hospital Campus