Throughout its complex lifecycle the malaria parasites, from the genus Plasmodium, must traverse tissues and invade a diversity of host cells to ensure successful propagation of their lifecycle. Each lifecycle stage is exquisitely designed for cell movement, tissue targeting, host cell invasion and replication, yet we still do not understand the basic mechanics of many of these key processes. Driven by this interest in understanding this parasite journey, our work covers the entirety of the parasite's lifecycle adventure from human blood to mosquito and back again, developing fundamental insights, finding new drug targets, designing innovative new therapeutics and laying the foundations for future antimalarial vaccines.