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@article{Foster:2026:10.1097/QAD.0000000000004533,
author = {Foster, C and Blenkinsop, A and Henderson, M and Lyall, H and Fidler, S and BONDY, study group},
doi = {10.1097/QAD.0000000000004533},
journal = {AIDS},
pages = {1459--1466},
title = {Risk factors associated with adverse metabolic health in youth with perinatally acquired HIV living in the United Kingdom.},
url = {http://dx.doi.org/10.1097/QAD.0000000000004533},
volume = {40},
year = {2026}
}
TY - JOUR
AB - OBJECTIVE: Non-AIDS-related morbidity and mortality in people with HIV are associated with adverse metabolic health, influenced by both traditional-related and HIV-related risk factors. There is a paucity of data for youth with perinatal HIV (PHIV). We explored the relationship between markers of metabolic health and antiretroviral therapy (ART) in youth with PHIV. DESIGN: Longitudinal observational cohort study; 26months. METHODS: Eighty-five youth enrolled in the 'Bone Density in Youth living with PHIV' (BONDY) underwent assessment of metabolic health including fasting biochemistry, BMI, total body dual energy x-ray absorptiometry scan and hepatic transient elastography. RESULTS: Of 85 participants with PHIV, mean age 21.7years, 58% were female and 82% black African. Median ART exposure was 15years, median CD4 + cell count 623cells/μl at enrolment with 82% viral load less than 200copies/ml. Median weight gain over 26months was 3kg, with BMI category overweight/obese increasing from 37 to 50% with 48% having dyslipidaemia. Metabolic syndrome criteria were fulfilled in 7%, with 13% having hypertension, 18% hepatic steatosis, and 7% fibrosis on transient elastography. Bayesian regression analyses demonstrated no association of integrase strand transfer inhibitor (INSTI) and/or tenofovir alafenamide (TAF) use, and sex at birth or prior CDC-C diagnoses or current HIV viraemia on metabolic outcomes. CONCLUSION: While adverse metabolic outcomes are common in this youth cohort with PHIV, no association was observed with INSTI and/or TAF use. Given the relatively young age of this cohort, preventative interventions targeting traditional metabolic risk factors are required to avoid comorbidities in later life.
AU - Foster,C
AU - Blenkinsop,A
AU - Henderson,M
AU - Lyall,H
AU - Fidler,S
AU - BONDY,study group
DO - 10.1097/QAD.0000000000004533
EP - 1466
PY - 2026///
SP - 1459
TI - Risk factors associated with adverse metabolic health in youth with perinatally acquired HIV living in the United Kingdom.
T2 - AIDS
UR - http://dx.doi.org/10.1097/QAD.0000000000004533
UR - https://www.ncbi.nlm.nih.gov/pubmed/42084121
VL - 40
ER -