BibTex format
@article{Warren:2017:10.1038/ng.3768,
author = {Warren, HR and Evangelou, E and Cabrera, CP and Gao, H and Ren, M and Mifsud, B and Ntalla, I and Surendran, P and Liu, C and Cook, JP and Kraja, AT and Drenos, F and Loh, M and Verweij, N and Marten, J and Karaman, I and Lepe, MP and O'Reilly, PF and Knight, J and Snieder, H and Kato, N and He, J and Tai, ES and Said, MA and Porteous, D and Alver, M and Poulter, N and Farrall, M and Gansevoort, RT and Padmanabhan, S and Mägi, R and Stanton, A and Connell, J and Bakker, SJ and Metspalu, A and Shields, DC and Thom, S and Brown, M and Sever, P and Esko, T and Hayward, C and van, der Harst P and Saleheen, D and Chowdhury, R and Chambers, JC and Chasman, DI and Chakravarti, A and Newton-Cheh, C and Lindgren, CM and Levy, D and Kooner, JS and Keavney, B and Tomaszewski, M and Samani, NJ and Howson, JM and Tobin, MD and Munroe, PB and Ehret, GB and Wain, LV and International, Consortium of Blood Pressure ICBP 1000G Analyses and BIOS, Consortium and Lifelines, Cohort Study and Understanding, },
doi = {10.1038/ng.3768},
journal = {Nature Genetics},
pages = {403--415},
title = {Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk},
url = {http://dx.doi.org/10.1038/ng.3768},
volume = {49},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
AU - Warren,HR
AU - Evangelou,E
AU - Cabrera,CP
AU - Gao,H
AU - Ren,M
AU - Mifsud,B
AU - Ntalla,I
AU - Surendran,P
AU - Liu,C
AU - Cook,JP
AU - Kraja,AT
AU - Drenos,F
AU - Loh,M
AU - Verweij,N
AU - Marten,J
AU - Karaman,I
AU - Lepe,MP
AU - O'Reilly,PF
AU - Knight,J
AU - Snieder,H
AU - Kato,N
AU - He,J
AU - Tai,ES
AU - Said,MA
AU - Porteous,D
AU - Alver,M
AU - Poulter,N
AU - Farrall,M
AU - Gansevoort,RT
AU - Padmanabhan,S
AU - Mägi,R
AU - Stanton,A
AU - Connell,J
AU - Bakker,SJ
AU - Metspalu,A
AU - Shields,DC
AU - Thom,S
AU - Brown,M
AU - Sever,P
AU - Esko,T
AU - Hayward,C
AU - van,der Harst P
AU - Saleheen,D
AU - Chowdhury,R
AU - Chambers,JC
AU - Chasman,DI
AU - Chakravarti,A
AU - Newton-Cheh,C
AU - Lindgren,CM
AU - Levy,D
AU - Kooner,JS
AU - Keavney,B
AU - Tomaszewski,M
AU - Samani,NJ
AU - Howson,JM
AU - Tobin,MD
AU - Munroe,PB
AU - Ehret,GB
AU - Wain,LV
AU - International,Consortium of Blood Pressure ICBP 1000G Analyses
AU - BIOS,Consortium
AU - Lifelines,Cohort Study
AU - Understanding,Society Scientific group
AU - CHD,Exome Consortium
AU - ExomeBP,Consortium
AU - T2D-GENES,Consortium
AU - GoT2DGenes,Consortium
AU - Cohorts,for Heart and Ageing Research in Genome Epidemiology CHARGE BP Exome Consortium
AU - International,Genomics of Blood Pressure iGEN-BP Consortium
AU - UK,Biobank CardioMetabolic Consortium BP working group
DO - 10.1038/ng.3768
EP - 415
PY - 2017///
SN - 1546-1718
SP - 403
TI - Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
T2 - Nature Genetics
UR - http://dx.doi.org/10.1038/ng.3768
UR - http://www.ncbi.nlm.nih.gov/pubmed/28135244
VL - 49
ER -
