Dopamine’s Role in Enhancing Attention and Memory (DREAM)

Overview

Traumatic brain injury (TBI) often leads to major cognitive problems, such as impairments of attention and memory. We are conducting a clinical trial of the drug methylphenidate as a cognitive enhancer in this population. Advanced MRI is being used why some patients develop these impairments and to try and predict the response of individuals to the drug. The drug increases dopamine levels in the brain. We are mapping damage to this system and using functional MRI to assess whether the drug normalises brain network function.


Principal investigator


Researchers involved

  • Pete Jenkins
  • Sara Di Simone

Funding

  • National Institute of Health Research

Figures

Measuring damage in the substantia nigra after traumatic brain injury
Measuring damage in the substantia nigra after traumatic brain injury