Neuroinflammation, amyloid and tau in subjects at risk of dementia

Overview

Amyloid imaging in a healthy (L) and control (R)
Amyloid imaging in a healthy (L) and control (R)

Alzheimer’s disease is a progressive neurodegenerative disease characterised by extracellular β-amyloid plaques and intracellular neurofibrillary tangles. In AD brain, it has been suggested that the accumulation of the amyloid-β peptide (Aβ) might responsible to develop the AD, which might due to overproduction of Aβ and/or the failure of clearance mechanisms.

The aim of this study is to find out how often brain changes with the protein build-up seen in some Alzheimer’s disease patients are seen in people with Mild Cognitive Impairment, and Alzheimer’s disease. You will be helping to gather information that could lead to the earlier diagnosis and better treatment of both Alzheimer’s disease and Mild Cognitive Impairment.

Researchers involved