About the speaker
Victor Tybulewicz is a Senior Group Leader and Associate Research Director at the Francis Crick Institute and a Professor at Imperial College. He has two main research interests. Firstly, he studies signal transduction pathways in lymphocytes that regulate development, activation, survival, migration and adhesion. Using mouse genetics, biochemistry and cell biology approaches he has defined multiple roles for the SYK kinase, the VAV1 exchange factor and for its substrates RAC1 and RAC2 in B and T cell physiology. Currently, he is studying a pathway controlled by the WNK1 kinase which plays a critical role in B and T cell activation, migration and adhesion. In addition, his group is interested in how BAFFR transduces signals that control B cell survival.
In a second research interest, in collaboration with Elizabeth Fisher (UCL) he has generated a series of mouse models of Down Syndrome (trisomy 21) and is using these to identify the genes that are required in three copies to cause specific Down Syndrome phenotypes, including congenital heart defects, craniofacial deficits and cognitive impairment.
For further information, please contact Professor Steve Ley s.ley@imperial.ac.uk
All are welcome to attend.