Lewis base-mediated reactions encompass a plethora of molecular transformations. Within this area, we have developed a range of catalytic (asymmetric) processes mediated by a range of Lewis bases.
This presentation will describe recent developments in the use of isothioureas to promote a number of selective transformations that involve the generation of either an acyl ammonium, ammonium enolate, a,b-unsaturated acyl ammonium or ylide intermediate.
The challenges associated with developing new strategies for catalyst turnover, as well as the application of these methodologies to the enantioselective synthesis of a variety of products, alongside mechanistic insights into these processes, will be discussed