Programme
12:00-12.15 Dr Lucy Wilson: “Delocalised chains and rings of ferrocene”
12:20-12.35 Dr David Pugh: “Main Group Alkoxides: Convenient Reagents for the Direct Formation of Amide Bonds”
12:40-13.25 Professor Steve Goldup: “The Synthesis of Complex Functional Interlocked Molecules”
Abstract: The Synthesis of Complex Funtional Interlocked Molecules
Our group have pioneered the use of “small” macrocycles[[i]] in active template reactions in order to allow the synthesis of small(er), functionalised rotaxanes in excellent yield.[[ii]] I will describe some of our recent applications of this methodology to the synthesis of complex homo-circuit and heterocircuit [n]rotaxanes[[iii],[iv][v]] as well as functional interlocked molecules including sensors and catalysts[[vi]] and discuss our pioneering work on mechanically chiral rotaxanes, a previously hard to access class of chiral molecules.[[vii]]
References:
[1] H. Lahlali, K. Jobe, M. Watkinson, S. M. Goldup, Angew. Chem., Int. Ed. 2011, 50, 4151.
[2] J. E. M. Lewis, R. J. Bordoli, M. Denis, C. J. Fletcher, M. Galli, E. A. Neal, E. M. Rochette, S. M. Goldup, Chem. Sci. 2016, 7, 3154.
[3] E. A. Neal, S. M. Goldup, Chem. Sci. 2015, 2398.
[4] E. A. Neal, S. M. Goldup, Angew. Chem. Int. Ed. 2016, 55, 12488.
[5] J. E. M. Lewis, J. Winn, L. Cera, S. M. Goldup J. Am. Chem. Soc. 2016, 138, 16329.
[6] M. Galli, J. E. M. Lewis, S. M. Goldup, Angew. Chem. Int. Ed. 2015, 54, 13545.
[7] R. J. Bordoli, S. M. Goldup, J. Am. Chem. Soc. 2014, 136, 4817.
BIO
Professor Stephen Goldup, University of Southampton
Steve obtained an MChem degree from the University of Oxford where he began his research career with a Part II project in the group of Sir Prof. Jack Baldwin. He continued his research training with a PhD in natural product synthesis under the supervision of Prof. Tony Barrett before shifting focus to apply his synthetic skills to the realisation of mechanically interlocked non-natural products during post doctoral work with Prof. David Leigh at the University of Edinburgh where in 2007 he was appointed as Fixed Term Lecturer in Organic Chemistry. In 2008 he moved to Queen Mary with the award of a Leverhulme Trust Early Career Fellowship and in October 2009 he was awarded a Royal Society University Research Fellowship. In October 2014 the group moved to the University of Southampton where Steve took up the position of Associate Professor. In 2017, he was promoted to Professor of Chemistry. Research in the Goldup Group focusses on the synthesis of novel mechanically interlocked molecules and their application as sensors, catalysts and materials.